A role for calreticulin in functioning of mitochondrial ATP-dependent potassium channel

被引：1
|
作者：
Shigaeva M.I. [1 ]
Talanov E.Y. [1 ]
Venediktova N.I. [1 ]
Murzaeva S.V. [2 ]
Mironova G.D. [1 ,2 ]
机构：
[1] Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region
[2] Pushchino State Institute of Natural Sciences, Pushchino, Moscow Region
来源：
Biophysics | 2014年 / 59卷 / 5期
关键词：
antibodies; calreticulin; mitochondria; mitochondrial ATP-dependent potassium channel; potassium transport in mitochondria;
D O I：
10.1134/S0006350914050236
中图分类号：
学科分类号：
摘要：
Homology of the amino acid sequence of the mitochondrial potassium-transporting protein (MW 57 kDa), having the properties of a channel subunit of the mitochondrial ATP-dependent potassium channel, and calreticulin (MW 55 kDa) was detected by MALDI-TOF-TOF analysis method. Inhibitory analysis of ATP-dependent potassium transport in mitochondria with polyclonal antibodies to calreticulin was carried out. A dose-dependent inhibition of potassium transport in mitochondria by these antibodies was shown. The maximum value of inhibition was 55–60%. Based on these data it is hypothesized that at least two types of ATP-sensitive potassium channels are localized in mitochondrial membrane. It is expected that the type of mitochondrial ATP-dependent potassium channel, which includes homologous calreticulin protein is localized mainly at mitochondrial and reticulum membrane contact sites. © 2014, Pleiades Publishing, Inc.
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页码：721 / 726
页数：5
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