Expansion of CD56Bright natural killer cells in the peripheral blood of multiple sclerosis patients treated with interferon-beta

被引：0
作者：
M. Saraste
H. Irjala
L. Airas
机构：
[1] University of Turku,MediCity Research Laboratory
[2] University of Turku,Department of Otorhinolaryngology
[3] University of Turku,Department of Neurology
来源：
Neurological Sciences | 2007年 / 28卷
关键词：
Interferon-beta; Multiple sclerosis; NK cell;
D O I：
暂无
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学科分类号：
摘要：
We studied how interferon-beta (IFN-β) treatment of relapsing-remitting multiple sclerosis (MS) affects subgroups of natural killer cells (NK cells). Following IFN-β treatment, there was an expansion of CD56Bright NK-cells in the peripheral blood of MS patients, while at the same time the proportion of CD56Dim cells was diminished. In a control group, the proportion of CD56Bright NK-cells was significantly higher in secondary lymphoid tissues compared to the peripheral blood of the same individual. Our findings confirm that CD56Bright NK-cells preferably locate within the secondary lymphoid tissues, where they may interact with T cells and thereby contribute to the control of the disease activity in MS.
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页码：121 / 126
页数：5
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