Expansion of CD56Bright natural killer cells in the peripheral blood of multiple sclerosis patients treated with interferon-beta

被引：0
作者：
M. Saraste
H. Irjala
L. Airas
机构：
[1] University of Turku,MediCity Research Laboratory
[2] University of Turku,Department of Otorhinolaryngology
[3] University of Turku,Department of Neurology
来源：
Neurological Sciences | 2007年 / 28卷
关键词：
Interferon-beta; Multiple sclerosis; NK cell;
D O I：
暂无
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学科分类号：
摘要：
We studied how interferon-beta (IFN-β) treatment of relapsing-remitting multiple sclerosis (MS) affects subgroups of natural killer cells (NK cells). Following IFN-β treatment, there was an expansion of CD56Bright NK-cells in the peripheral blood of MS patients, while at the same time the proportion of CD56Dim cells was diminished. In a control group, the proportion of CD56Bright NK-cells was significantly higher in secondary lymphoid tissues compared to the peripheral blood of the same individual. Our findings confirm that CD56Bright NK-cells preferably locate within the secondary lymphoid tissues, where they may interact with T cells and thereby contribute to the control of the disease activity in MS.
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页码：121 / 126
页数：5
相关论文
共 78 条
[1]  
Viglietta V.(2004)Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis J Exp Med 199 971-979
[2]  
Baecher-Allan C.(2004)The regulatory role of natural killer cells in multiple sclerosis Brain 127 1917-1927
[3]  
Weiner H.L.(2001)Natural killer type 2 bias in remission of multiple sclerosis J Clin Invest 107 R23-R29
[4]  
Hafler D.A.(2005)Frequency of blood CX3CR1-positive natural killer cells correlates with disease activity in multiple sclerosis patients FASEB J 19 1902-1904
[5]  
Takahashi K.(1996)Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis. The Multiple Sclerosis Collaborative Research Group (MSCRG) Ann Neurol 39 285-294
[6]  
Aranami T.(2002)Differential mechanisms of action of interferon-beta and glatiramer acetate in MS Neurology 59 802-808
[7]  
Endoh M.(2000)Effect of IFNbeta and anti-IFNbeta antibodies on NK cells in multiple sclerosis patients J Neuroimmunol 105 91-95
[8]  
Takahashi K.(1998)A role for natural killer cells in the immunopathogenesis of multiple sclerosis J Neuroimmunol 86 123-133
[9]  
Miyake S.(2001)The biology of human natural killer-cell subsets Trends Immunol 22 633-640
[10]  
Kondo T.(2005)Cutting edge: in vivo blockade of human IL-2 receptor induces expansion of CD56(bright) regulatory NK cells in patients with active uveitis J Immunol 174 5187-5191
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