Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice

被引：0
|
作者：
Tsutomu Sasaki
Osamu Kikuchi
Mayumi Shimpuku
Vina Yanti Susanti
Hiromi Yokota-Hashimoto
Ryo Taguchi
Nobuyuki Shibusawa
Takashi Sato
Lijun Tang
Kosuke Amano
Tomoya Kitazumi
Mitsutaka Kuroko
Yuki Fujita
Jun Maruyama
Yong-soo Lee
Masaki Kobayashi
Takashi Nakagawa
Yasuhiko Minokoshi
Akihiro Harada
Masanobu Yamada
Tadahiro Kitamura
机构：
[1] Gunma University,Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation
[2] Gunma University,Department of Medicine and Molecular Science, Graduate School of Medicine
[3] Gunma University,Laboratory of Molecular Traffic, Department of Molecular and Cellular Biology, Institute for Molecular and Cellular Regulation
[4] National Institute for Physiological Sciences,Division of Endocrinology and Metabolism, Department of Developmental Physiology
[5] University of Toyama,Frontier Research Core for Life Science
[6] Osaka University,Department of Cell Biology, Graduate School of Medicine
来源：
Diabetologia | 2014年 / 57卷
关键词：
AgRP; Brown adipose tissue; Diet-induced obesity; Energy expenditure; Food intake; Hypothalamus; Leptin sensitivity; NAD; POMC; Sympathetic activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：819 / 831
页数：12
相关论文
共 32 条
  • [21] Increased body weight in mice with fragile X messenger ribonucleoprotein 1 (Fmr1) gene mutation is associated with hypothalamic dysfunction
    Ruggiero-Ruff, Rebecca E.
    Villa, Pedro A.
    Hijleh, Sarah Abu
    Avalos, Bryant
    DiPatrizio, Nicholas V.
    Haga-Yamanaka, Sachiko
    Coss, Djurdjica
    SCIENTIFIC REPORTS, 2023, 13 (01)
  • [22] SOCS3 expression within leptin receptor-expressing cells regulates food intake and leptin sensitivity but does not affect weight gain in pregnant mice consuming a high-fat diet
    Zampieri, Thais Tessari
    Oliveira da Silva, Tiago Eugenio
    Romeu, Deborah de Paula
    Torrao, Andrea da Silva
    Donato, Jose, Jr.
    PHYSIOLOGY & BEHAVIOR, 2016, 157 : 109 - 115
  • [23] Miglitol protects against age-dependent weight gain in mice: A potential role of increased UCP1 content in brown adipose tissue
    Sasaki, Tsutomu
    Hiraga, Haruna
    Yokota-Hashimoto, Hiromi
    Kitamura, Tadahiro
    ENDOCRINE JOURNAL, 2015, 62 (05) : 469 - 473
  • [24] Improved leptin sensitivity and increased soluble leptin receptor concentrations may underlie the additive effects of combining PYY [1-34] and exendin-4 on body weight lowering in diet-induced obese mice
    Wulff, Birgitte S.
    Kuhre, Rune Ehrenreich
    Selvaraj, Madhan
    Rehfeld, Jens F.
    Niss, Kristoffer
    Fels, Johannes J.
    Anna, Secher
    Raun, Kirsten
    Gerstenberg, Marina Kjaergaard
    HELIYON, 2024, 10 (12)
  • [25] Increased Sirt1 secreted from visceral white adipose tissue is associated with improved glucose tolerance in obese Nrf2-deficient mice
    Braud, Laura
    Pini, Maria
    Stec, Donald F.
    Manin, Sylvie
    Derumeaux, Genevieve
    Stec, David E.
    Foresti, Roberta
    Motterlini, Roberto
    REDOX BIOLOGY, 2021, 38
  • [26] Neuropeptide Y (NPY) Y1 receptor mRNA is upregulated in association with transient hyperphagia and body weight gain: Evidence for a hypothalamic site for concurrent development of leptin resistance
    Kalra, PS
    Dube, MG
    Xu, B
    Farmerie, WG
    Kalra, SP
    JOURNAL OF NEUROENDOCRINOLOGY, 1998, 10 (01) : 43 - 49
  • [27] Levamisole: A Positive Allosteric Modulator for the α3β4 Nicotinic Acetylcholine Receptors Prevents Weight Gain in the CD-1 Mice on a High Fat Diet
    Lewis, Jeanne A.
    Yakel, Jerrel L.
    Pandya, Anshul A.
    CURRENT PHARMACEUTICAL DESIGN, 2017, 23 (12) : 1869 - 1872
  • [28] The effects of serotonin1A receptor on female mice body weight and food intake are associated with the differential expression of hypothalamic neuropeptides and the GABAA receptor
    Butt, Isma
    Hong, Andrew
    Di, Jing
    Aracena, Sonia
    Banerjee, Probal
    Shen, Chang-Hui
    NEUROPEPTIDES, 2014, 48 (05) : 313 - 318
  • [29] Whole Body Ip6k1 Deletion Protects Mice from Age-Induced Weight Gain, Insulin Resistance and Metabolic Dysfunction
    Ghoshal, Sarbani
    Mukherjee, Sandip
    Chakraborty, Molee
    Msengi, Eliwaza Naomi
    Haubner, Jake
    Chakraborty, Anutosh
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (04)
  • [30] Compared to casein, bovine lactoferrin reduces plasma leptin and corticosterone and affects hypothalamic gene expression without altering weight gain or fat mass in high fat diet fed C57/BL6J mice
    McManus, Bettina
    Korpela, Riitta
    O'Connor, Paula
    Schellekens, Harriet
    Cryan, John F.
    Cotter, Paul D.
    Nilaweera, Kanishka N.
    NUTRITION & METABOLISM, 2015, 12
1234