Common challenges and problems in clinical trials of boron neutron capture therapy of brain tumors

被引：0
作者：
N. Gupta
R.A. Gahbauer
T.E. Blue
B. Albertson
机构：
[1] Division of Radiation Oncology, Ohio State University, Columbus, OH
[2] Nuclear Engineering Program, Ohio State University, Columbus, OH
来源：
Journal of Neuro-Oncology | 2003年 / 62卷 / 1期
关键词：
BNCT; Boron uptake; Clinical trials; Epithermal beam; Treatment data reporting;
D O I：
10.1023/A:1023286919318
中图分类号：
学科分类号：
摘要：
Clinical trials for binary therapies, like boron neutron capture therapy (BNCT), pose a number of unique problems and challenges in design, performance, and interpretation of results. In neutron beam development, different groups use different optimization parameters, resulting in beams being considerably different from each other. The design, development, testing, execution of patient pharmacokinetics and the evaluation of results from these studies differ widely. Finally, the clinical trials involving patient treatments vary in many aspects such as their dose escalation strategies, treatment planning methodologies, and the reporting of data. The implications of these differences in the data accrued from these trials are discussed. The BNCT community needs to standardize each aspect of the design, implementation, and reporting of clinical trials so that the data can be used meaningfully.
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页码：197 / 210
页数：13
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