Cardiorenal Syndrome: Pathophysiology and Treatment

被引：0
作者：
Dmitry Shchekochikhin
Robert W. Schrier
JoAnn Lindenfeld
机构：
[1] I.M.Setchenov’s First Moscow State Medical University,Department of Preventive and Emergency Cardiology
[2] University of Colorado Denver,undefined
[3] University of Colorado Denver,undefined
来源：
Current Cardiology Reports | 2013年 / 15卷
关键词：
Cardiorenal syndrome; CRS; Arterial underfilling; Ultrafiltration; Heart failure; Worsening renal function;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
CRS is a common problem in patients with advanced heart failure. Arterial underfilling with consequent neurohormonal activation, systemic and intrarenal vasoconstriction, and salt and water retention cause the main clinical features of CRS which include a progressive decline in renal function, worsening renal function during treatment of heart failure (HF) decompensation and resistance to loop diuretics. Impaired renal function in HF patients often reflects more advanced stages of cardiac failure, and thus is associated with a worse prognosis. However, a transient fall in glomerular filtration rate may be a result of successful treatment of congestion, and thereby might not be associated with decreased survival in HF patients. This review covers basic pathophysiological mechanisms underlying the CRS and current trends in practical approaches to treat these patients.
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