Efficient and selective N-alkylation of amines with alcohols catalysed by manganese pincer complexes

被引：0
作者：
Saravanakumar Elangovan
Jacob Neumann
Jean-Baptiste Sortais
Kathrin Junge
Christophe Darcel
Matthias Beller
机构：
[1] Leibniz-Institut für Katalyse e.V. an der Universität Rostock,
[2] UMR 6226 CNRS—Université de Rennes 1 Institut des Sciences Chimiques de Rennes,undefined
[3] Team Organometallics: Materials and Catalysis—Centre for Catalysis and Green Chemistry,undefined
来源：
Nature Communications | / 7卷
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摘要：
Borrowing hydrogen (or hydrogen autotransfer) reactions represent straightforward and sustainable C–N bond-forming processes. In general, precious metal-based catalysts are employed for this effective transformation. In recent years, the use of earth abundant and cheap non-noble metal catalysts for this process attracted considerable attention in the scientific community. Here we show that the selective N-alkylation of amines with alcohols can be catalysed by defined PNP manganese pincer complexes. A variety of substituted anilines are monoalkylated with different (hetero)aromatic and aliphatic alcohols even in the presence of other sensitive reducible functional groups. As a special highlight, we report the chemoselective monomethylation of primary amines using methanol under mild conditions.
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