Inhaled aviptadil for the possible treatment of COVID-19 in patients at high risk for ARDS: study protocol for a randomized, placebo-controlled, and multicenter trial

被引:0
作者
Maria Boesing
Kristin Abig
Michael Brändle
Martin Brutsche
Emanuel Burri
Björn C. Frye
Stéphanie Giezendanner
Jan C. Grutters
Philippe Haas
Justian Heisler
Fabienne Jaun
Anne B. Leuppi-Taegtmeyer
Giorgia Lüthi-Corridori
Joachim Müller-Quernheim
Reto Nüesch
Wolfgang Pohl
Frank Rassouli
Jörg D. Leuppi
机构
[1] University Clinic of Medicine,Faculty of Medicine
[2] Cantonal Hospital Baselland,Department of Pneumology
[3] University of Basel,Division of Heart & Lungs
[4] Cantonal Hospital St. Gallen,Department of Clinical Pharmacology and Toxicology
[5] Medical Center University of Freiburg,undefined
[6] St. Antonius Hospital Nieuwegein,undefined
[7] University Medical Center Utrecht,undefined
[8] AdVita Lifescience GmbH,undefined
[9] University Hospital Basel,undefined
[10] University of Basel,undefined
[11] Hospital Schwyz,undefined
[12] Karl Landsteiner Institute for Clinical and Experimental Pneumology,undefined
[13] Clinic Hietzing,undefined
来源
Trials | / 23卷
关键词
Aviptadil; VIP; COVID-19; ARDS; SARS-CoV-2;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 231 条
[31]  
Hammond J(1999)Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activation polypeptide (PACAP) protect mice from lethal endotoxemia through the inhibition of TNF-alpha and IL-6 J Immunol (Baltimore, Md: 1950) 162 1200-275
[32]  
Leister-Tebbe H(2002)New evidence for transmitter role of VIP in the airways: impaired relaxation by a catalytic antibody Pulm Pharmacol Ther 15 121-2551
[33]  
Gardner A(2007)Role of c-fos gene in vasoactive intestinal peptide promoted synthesis of pulmonary surfactant phospholipids Regul Pept 140 117-876
[34]  
Abreu P(2010)Inhaled vasoactive intestinal peptide exerts immunoregulatory effects in sarcoidosis Am J Respir Crit Care Med 182 540-2574
[35]  
Bao W(2015)Vasoactive intestinal peptide suppresses macrophage-mediated inflammation by downregulating interleukin-17A expression via PKA- and PKC-dependent pathways Int J Exp Pathol 96 269-1346
[36]  
Wisemandle W(2010)Vasoactive intestinal peptide induces cell cycle arrest and regulatory functions in human T cells at multiple levels Mol Cell Biol 30 2537-1294
[37]  
Jayk Bernal A(2006)Vasoactive intestinal peptide induces CD4+,CD25+ T regulatory cells with therapeutic effect in collagen-induced arthritis Arthritis Rheum 54 864-8125
[38]  
Gomes da Silva MM(2020)Vasoactive intestinal peptide in checkpoint inhibitor-induced pneumonitis N Engl J Med 382 2573-1937
[39]  
Musungaie DB(2003)Vasoactive intestinal peptide as a new drug for treatment of primary pulmonary hypertension J Clin Invest 111 1339-470
[40]  
Kovalchuk E(2008)Inhalation of vasoactive intestinal peptide in pulmonary hypertension Eur Respir J 32 1289-943