Psychophysiological approach in Parkinson's disease: L-dopa effects on preprogramming and control activity

被引：0

作者：

F. Fattapposta

F. Pierelli

F. My

M. Mostarda

S. Del Monte

L. Parisi

M. Serrao

N. Locuratolo

G. Amabile

机构：

[1] Clinical Institute of Nervous and Mental Diseases,

[2] La Sapienza University,undefined

[3] Viale dell'Università,undefined

[4] 30,undefined

[5] I-00185 Rome,undefined

[6] Italy,undefined

[7] IRCCS Neuromed,undefined

[8] Pozzilli (IS),undefined

[9] Italy,undefined

来源：

Neurological Sciences | 2002年 / 23卷

关键词：

Control Activity; Performance Positivity; Skilled Performance; Motor Strategy; Dopaminergic Drug;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

To investigate whether preprogramming (Bereitschaftspotential, BP) and control activity (skilled performance positivity, SPP) in a complex task are sensitive to L-dopa, movement related potentials (MRPs) were recorded in 12 non-demented Parkinson's disease (PD) patients before and after acute L-dopa administration, and in 17 control subjects. After L-dopa administration, the PD patients scored a significantly higher percentage of correct performances (p<0.05), linked to a decreased BP amplitude (p<0.001) and an increased SPP amplitude (p<0.005), than before therapy. Our findings suggest that preprogramming activity is impaired in untreated PD patients. Dopaminergic drug administration seems to restore their ability to use more automatic motor strategies which become more similar to that of normal subjects.

引用

页码：s73 / s74