Microbial colonization influences early B-lineage development in the gut lamina propria

被引：0
作者：
Duane R. Wesemann
Andrew J. Portuguese
Robin M. Meyers
Michael P. Gallagher
Kendra Cluff-Jones
Jennifer M. Magee
Rohit A. Panchakshari
Scott J. Rodig
Thomas B. Kepler
Frederick W. Alt
机构：
[1] Children’s Hospital Boston,Program in Cellular and Molecular Medicine and Department of Medicine
[2] Boston,Department of Genetics
[3] Massachusetts 02115,Division of Rheumatology, Department of Medicine
[4] USA,Department of Pathology
[5] Harvard Medical School,Department of Microbiology
[6] Boston,undefined
[7] Massachusetts 02115,undefined
[8] USA,undefined
[9] Howard Hughes Medical Institute,undefined
[10] Boston,undefined
[11] Massachusetts 02115,undefined
[12] USA,undefined
[13] Immunology and Allergy,undefined
[14] Brigham and Women’s Hospital,undefined
[15] Boston,undefined
[16] Massachusetts 02115,undefined
[17] USA,undefined
[18] Brigham and Women’s Hospital,undefined
[19] Boston,undefined
[20] Massachusetts 02115,undefined
[21] USA,undefined
[22] Boston University School of Medicine,undefined
[23] Boston,undefined
[24] Massachusetts 02215,undefined
[25] USA,undefined
来源：
Nature | 2013年 / 501卷
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学科分类号：
摘要：
Primary B-cell development is thought to be restricted to the bone marrow; here it is shown to occur also in intestinal tissues of postnatal mice, that it peaks at the time of weaning and is increased upon colonization of germ-free mice, and is thus influenced by commensal microbes.
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页码：112 / 115
页数：3
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