Enterotypes in the landscape of gut microbial community composition

被引:0
作者
Paul I. Costea
Falk Hildebrand
Manimozhiyan Arumugam
Fredrik Bäckhed
Martin J. Blaser
Frederic D. Bushman
Willem M. de Vos
S. Dusko Ehrlich
Claire M. Fraser
Masahira Hattori
Curtis Huttenhower
Ian B. Jeffery
Dan Knights
James D. Lewis
Ruth E. Ley
Howard Ochman
Paul W. O’Toole
Christopher Quince
David A. Relman
Fergus Shanahan
Shinichi Sunagawa
Jun Wang
George M. Weinstock
Gary D. Wu
Georg Zeller
Liping Zhao
Jeroen Raes
Rob Knight
Peer Bork
机构
[1] European Molecular Biology Laboratory,Laboratory of Microbiology
[2] VIB Center for Microbiology,The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences
[3] Vrije Universiteit Brussel,Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy
[4] University of Copenhagen,Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Receptology and Enteroendocrinology, Faculty of Health Sciences
[5] University of Gothenburg,Department of Microbiology
[6] University of Copenhagen,RPU Immunobiology, Department of Bacteriology & Immunology
[7] New York University Langone Medical Center,Laboratory of Microbiology
[8] Perelman School of Medicine at the University of Pennsylvania,Metagenopolis
[9] University of Helsinki,King’s College London, Centre for Host
[10] Wageningen University,Microbiome Interactions
[11] Institut National de la Recherche Agronomique,Graduate School of Advanced Science and Engineering
[12] Dental Institute Central Office,Department of Biostatistics
[13] Guy’s Hospital,APC Microbiome Institute
[14] Institute for Genome Sciences at the University of Maryland School of Medicine,Biotechnology Institute
[15] Waseda University,Department of Computer Science and Engineering
[16] Harvard School of Public Health,Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine
[17] University College Cork,Department of Integrative Biology
[18] University of Minnesota,Warwick Medical School
[19] University of Minnesota,Department of Microbiology and Immunology
[20] University of Pennsylvania,Department of Medicine
[21] MPI Department of Microbiome Science,Department of Biology, Institute of Microbiology
[22] University of Texas,Department of Biology
[23] University of Warwick,Princess Al Jawhara Albrahim Center of Excellence in the Research of Hereditary Disorders
[24] Stanford University,Department of Medicine and State Key Laboratory of Pharmaceutical Biotechnology
[25] Stanford University,Division of Gastroenterology, Perelman School of Medicine
[26] Veterans Affairs Palo Alto Health Care System,Ministry of Education Key Laboratory for Systems Biomedicine, Shanghai Centre for Systems Biomedicine
[27] ETH Zurich,Department of Microbiology and Immunology
[28] University of Copenhagen,Department of Computer Science
[29] King Abdulaziz University,Biofrontiers Institute
[30] Macau University of Science and Technology,Department of Chemistry and Biochemistry
[31] University of Hong Kong,Howard Hughes Medical Institute
[32] The Jackson Laboratory for Genomic Medicine,undefined
[33] University of Pennsylvania,undefined
[34] Shanghai Jiao Tong University,undefined
[35] Rega Institute KU Leuven,undefined
[36] University of Colorado,undefined
[37] University of Colorado,undefined
[38] University of Colorado,undefined
[39] University of Colorado,undefined
[40] Max-Delbrück-Centre for Molecular Medicine,undefined
[41] Molecular Medicine Partnership Unit,undefined
来源
Nature Microbiology | 2018年 / 3卷
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摘要
Population stratification is a useful approach for a better understanding of complex biological problems in human health and wellbeing. The proposal that such stratification applies to the human gut microbiome, in the form of distinct community composition types termed enterotypes, has been met with both excitement and controversy. In view of accumulated data and re-analyses since the original work, we revisit the concept of enterotypes, discuss different methods of dividing up the landscape of possible microbiome configurations, and put these concepts into functional, ecological and medical contexts. As enterotypes are of use in describing the gut microbial community landscape and may become relevant in clinical practice, we aim to reconcile differing views and encourage a balanced application of the concept.
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页码:8 / 16
页数:8
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