Use of Pen-Based Electronic Diaries in An International Clinical Trial of Asthma

The use of pen-based electronic diaries was evaluated in an international clinical trial of asthma. The study compared bambuterol with salmeterol in nocturnal asthma, and was carried out in Italy, Norway, and the United Kingdom. Two hundred and sixty-five patients were enrolled, of whom 135 were randomized and 118 completed the eight-week study period. Patients completed the electronic diary at home each morning and evening throughout the eight-week study period. Data could be entered into the diary only within specified time” “windows.” No retrospective entry was permitted.