Successful lysis of an obstructive aortic and renal artery thrombus in a neonate on extracorporeal membrane oxygenation

被引:4
作者
Gunnarsson B. [1 ,4 ]
Heard C.M.B. [1 ,2 ]
Martin D.J. [3 ]
Brecher M.L. [1 ]
Steinhorn R.H. [1 ]
机构
[1] Department of Pediatrics, Children's Hospital of Buffalo, State Univ. of New York at Buffalo, Buffalo, NY
[2] Department of Anesthesiology, Children's Hospital of Buffalo, State Univ. of New York at Buffalo, Buffalo, NY
[3] Department of Radiology, Children's Hospital of Buffalo, State Univ. of New York at Buffalo, Buffalo, NY
[4] Division of Pediatric Critical Care, Children's Hospital of Buffalo, Buffalo, NY 14222-2099
关键词
D O I
10.1038/sj.jp.7200466
中图分类号
学科分类号
摘要
We describe a neonate on venoarterial extracorporeal membrane oxygenation (ECMO) with acute renal failure associated with extensive aortic and bilateral renal artery thrombosis. Concurrent anticoagulation and continuous systemic thrombolytic therapy with tissue plasminogen activator (t-PA) resulted in complete thrombolysis as evaluated by Doppler flow. The relative risk and benefits of thrombolytic therapy in heparinized patients undergoing ECMO needs to be further studied.
引用
收藏
页码:555 / 557
页数:2
相关论文
共 25 条
[1]  
Seibert J.J., Taylor B.J., Williamson S.L., Szabo J.S., Corbitt S.L., Sonographic detection of neonatal umbilical artery thrombosis: Clinical correlation, Am J Roentgenol, 148, pp. 965-968, (1987)
[2]  
Goetzman B.W., Stadalnik R.C., Bogren H.G., Blankenship W.J., Ikeda R.M., Thayer J., Thrombotic complications of umbilical artery catheters: A clinical and radiographic study, Pediatrics, 56, pp. 374-379, (1975)
[3]  
Ankola P.A., Atakent Y.S., Effect of adding heparin in very low concentration to the infusate to prolong the patency of umbilical artery catheters, Am J Perinatal, 10, pp. 229-232, (1993)
[4]  
Vailas G.N., Brouillette R.T., Scott J.P., Shkolnik A., Conway J., Wiringa K., Neonatal aortic thrombosis: Recent experience, J Pediatr, 109, pp. 101-108, (1986)
[5]  
Ahluwalia J.S., Kelsall A.W.R., Diederich S., Rennie J.M., Successful treatment of aortic thrombosis after umbilical catheterization with tissue plasminogen activator, Acta Paediatr, 83, pp. 1215-1217, (1994)
[6]  
Torkington J., Hitchcock R., Wilkinson K., Kiely E., Successful use of recombinant tissue plasminogen activator in the treatment of aortic thrombosis is a premature neonate, Eur J Vase Endovasc Surg, 13, pp. 515-516, (1997)
[7]  
Ellis D., Kaye R.D., Bontempo F.A., Aortic and renal artery thrombosis in a neonate: Recovery with thrombolytic therapy, Pediatr Nephrol, 11, 5, pp. 641-644, (1997)
[8]  
Leaker M., Massicotte M.P., Brooker I.A., Andrew M., Thrombolytic therapy in pediatric patients: A comprehensive review of the litterature, Thromb Haemost, 76, 2, pp. 132-134, (1996)
[9]  
Smets K., Vanhaesebrouck P., Voet D., Schelstraete P., Govaert P., Use of tissue type plasminogen activator in neonates: Case reports and review of the litterature, Am J Perinatol, 13, pp. 217-222, (1996)
[10]  
Kennedy L.A., Drummond W.H., Knight M.E., Millsaps M.M., Williams J.L., Successful treatment of neonatal aortic thrombosis with tissue plasminogen activator, J Pediatr, 116, 5, pp. 798-801, (1990)