Decrease of CD4+ T-lymphocytes in children exposed to environmental lead

被引：2
作者：
Sun Li
Zhao Zhengyan
Li Rong
Cheng Hanyun
机构：
[1] Zhejiang University,The Children's Hospital of Medical College
来源：
Biological Trace Element Research | 2005年 / 105卷
关键词：
Environmental lead exposure; preschool children; lymphocyte;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The effects of environmental lead on the immune system of young children were assessed by determining the peripheral blood lymphocytes CD3+, CD4+, CD8+, B(CD19+) counts, and natural killer (CD16+ CD56+) cells in 35 preschool children whose mean blood lead level was 140.6 μg/L. The results were compared to an age- and sex-matched control group with a mean blood lead level of 64.3 μg/L. Compared to the controls, a significant reduction in the percentage of CD4+ cells and a significant increase of CD8+ cells were seen in the high-lead group. The negative correlation between the percentage of CD4+ cells and blood lead levels was found to be significant (p<0.01). These results suggest that exposure to environmental lead might result in alterations in the immune function of young children.
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页码：19 / 25
页数：6
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