Combined targeting of MDM2 and CDK4 is synergistic in dedifferentiated liposarcomas

被引:0
|
作者
Audrey Laroche-Clary
Vanessa Chaire
Marie-Paule Algeo
Marie-Alix Derieppe
François L. Loarer
Antoine Italiano
机构
[1] Université de Bordeaux,Department of Medical Oncology
[2] Institut National de la Santé et de la Recherche Medicale (INSERM) U1218,undefined
[3] Institut Bergonié,undefined
[4] Institut Bergonié,undefined
关键词
MDM2; CDK4; Well-differentiated/dedifferentiated liposarcomas;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [41] Expression of MDM2 and CDK4 in angiomyolipomas: A potential pitfall in differential diagnosis
    Nascimento, A. F.
    Dal Cin, P.
    Hornick, J. L.
    MODERN PATHOLOGY, 2008, 21 : 173A - 173A
  • [42] Clinical and biological significance of CDK4 amplification in well-differentiated and dedifferentiated liposarcomas
    Italiano, A.
    Bianchini, L.
    Keslair, F.
    Cardot, N.
    Mainguene, C.
    Ranchere-Vince, D.
    Terrier, P.
    Leroux, A.
    Coindre, J. M.
    Pedeutour, F.
    EJC SUPPLEMENTS, 2008, 6 (09): : 110 - 110
  • [43] Expression of MDM2 and CDK4 in angiomyolipomas: A potential pitfall in differential diagnosis
    Nascimento, A. F.
    Dal Cin, P.
    Hornick, J. L.
    LABORATORY INVESTIGATION, 2008, 88 : 173A - 173A
  • [44] Can MDM2 and CDK4 make the diagnosis of well differentiated/dedifferentiated liposarcoma? An immunohistochemical study on 129 soft tissue tumours
    Aleixo, P. B.
    Hartmann, A. A.
    Menezes, I. C.
    Meurer, R. T.
    Oliveira, A. M.
    JOURNAL OF CLINICAL PATHOLOGY, 2009, 62 (12) : 1127 - 1135
  • [45] Co-amplification of CDK4 and MDM2 plus HMGA2 fusion in a patient with myogenic differentiation dedifferentiated liposarcoma.
    Huang, Gang
    Li, Xianan
    Wang, Chunyang
    He, Qifan
    Wang, Xiaojuan
    CANCER RESEARCH, 2021, 81 (13)
  • [46] The value of MDM2 and CDK4 amplification levels using real-time PCR and fish for the differential diagnosis of liposarcomas and their histologic mimickers
    Hirose, Takanori
    Shimada, Shio
    Ishizawa, Keisuke
    Harada, Hiroshi
    Matsumura, Tadaki
    Hasegawa, Tadashi
    MODERN PATHOLOGY, 2006, 19 : 181 - 181
  • [47] Diagnostic Utility and Limitations of Immunohistochemistry of p16, CDK4, and MDM2 and Automated Dual-color In Situ Hybridization of MDM2 for the Diagnosis of Challenging Cases of Dedifferentiated Liposarcoma
    Kobayashi, Anna
    Sakuma, Toshiko
    Fujimoto, Masayo
    Jimbo, Naoe
    Hirose, Takanori
    APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY, 2019, 27 (10) : 758 - 763
  • [48] Prognostic value of HMGA2, CDK4, and JUN amplification in well-differentiated and dedifferentiated liposarcomas
    Saada-Bouzid, Esma
    Burel-Vandenbos, Fanny
    Ranchere-Vince, Dominique
    Birtwisle-Peyrottes, Isabelle
    Chetaille, Bruno
    Bouvier, Corinne
    Chateau, Marie-Christine
    Peoc'h, Michel
    Battistella, Maxime
    Bazin, Audrey
    Gal, Jocelyn
    Michiels, Jean-Francois
    Coindre, Jean-Michel
    Pedeutour, Florence
    Bianchini, Laurence
    MODERN PATHOLOGY, 2015, 28 (11) : 1404 - 1414
  • [49] Genomic amplification of CDK4 in dedifferentiated liposarcomas as a predictive biomarker for microtubule disrupting agents.
    Demoret, Bryce
    Rogers, Andrew
    Seligson, Nathan David
    Kautto, Esko Antero
    Hays, John L.
    Chen, James Lin
    JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (15)
  • [50] CDK4 inhibition diminishes p53 activation by MDM2 antagonists
    Sriraman, Anusha
    Dickmanns, Antje
    Najafova, Zeynab
    Johnsen, Steven A.
    Dobbelstein, Matthias
    CELL DEATH & DISEASE, 2018, 9