Migraine genetics

被引：19
作者：
Esther Kors
Joost Haan
Michel Ferrari
机构：
[1] Department of Neurology, Leiden University Medical Centre, 2300 RC Leiden
来源：
Current Pain and Headache Reports | 2003年 / 7卷 / 3期
关键词：
Migraine; Essential Tremor; Migraine With Aura; Cortical Spreading Depression; Migraine Without Aura;
D O I：
10.1007/s11916-003-0075-4
中图分类号：
学科分类号：
摘要：
The genetics of migraine is a fascinating and moving research area. Familial hemiplegic migraine, a rare subtype of migraine with a Mendelian pattern of inheritance, is caused by mutations in the chromosome 19 CACNA1A gene in approximately 75% of the families. The finding of mutations in an ionchannel subunit defines migraine as a channelopathy (eg, epilepsy). The genetics of the more frequent variants, migraine with and without aura, is more complex. Several loci have been studied in families and case-control studies, but need to be confirmed. Copyright © 2003 by Current Science Inc.
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页码：212 / 217
页数：5
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