Effect of atmospheric ammonia on mortality rate of rats with barbiturate intoxication

被引：0
|
作者：
V. L. Rejniuk
T. V. Schafer
R. V. Ovsep’yan
J. J. Ivnitsky
机构：
[1] Military Medical Academy,
来源：
Bulletin of Experimental Biology and Medicine | 2007年 / 143卷
关键词：
sodium thiopental; atmospheric ammonia; blood ammonia; ammonium acetate; mortality;
D O I：
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摘要：
Ammonia inhalation (0.84–1.07 mg/liter, 3 h) was accompanied by a 65% increase in ammonia concentration in mixed blood of intact rats. This treatment did not cause death of intact animals, but potentiated the lethal effect of sodium thiopental and inhibited external respiration and O2 consumption in animals. The resistance of rats to the lethal effect of barbiturate tended to decrease under conditions of experimental hyperammonemia induced by intraperitoneal injection of ammonium acetate in a nonlethal dose (6 mmol/kg). Our results indicate that potentiation of the toxic effect of barbiturates by atmospheric ammonia is related to its resorptive effects.
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