Growth inhibition of DMBA-induced rat mammary carcinomas by UK 114

被引：0
|
作者：
Silvia Racca
Francesco Di Carlo
Alberto Bartorelli
Benedetta Bussolati
G. Bussolati
机构：
[1] Department of Biological and Clinical Sciences,
[2] University of Turin,undefined
[3] Turin,undefined
[4] Italy,undefined
[5] ”G. Sisini” Institute,undefined
[6] University of Milan,undefined
[7] Milan,undefined
[8] Italy,undefined
[9] Department of Medical and Surgical Sciences,undefined
[10] University of Turin,undefined
[11] Turin,undefined
[12] Italy,undefined
[13] Department of Biomedical Sciences and Human Oncology,undefined
[14] University of Turin,undefined
[15] Via Santena 7,undefined
[16] I-10126 Torino,undefined
[17] Italy Tel.: (39) 11-6706505; Fax: (39) 11-6635267,undefined
来源：
Virchows Archiv | 1997年 / 431卷
关键词：
Key words Immunosurveillance; Cytotoxicity; Neoplasms; Dimethylbenzanthracene; Rats;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
 A perchloric acid-soluble protein extracted from goat liver and designated as UK 114 is known to be expressed over the cell membrane of (some) human cancer cell lines. This protein is antigenic, and specific antibodies elicit complement-dependent cytolysis of neoplastic target cells. In this study we demonstrate that administration of UK 114, either pure or as a crude extract (designated UK 101), inhibits the growth of mammary carcinomas induced in female Sprague-Dawley rats by dimethylbenzanthracene (DMBA). The mechanism of the tumour inhibitory activity of UK 114 is probably related to induction of immunosurveillance.
引用
收藏
页码：323 / 328
页数：5
相关论文
共 50 条
  • [41] SHOCK STRESS AND DMBA-INDUCED MAMMARY TUMORS
    NEWBERRY, BH
    FRANKIE, G
    BEATTY, PA
    MALONEY, BD
    GILCHRIST, JC
    PSYCHOSOMATIC MEDICINE, 1972, 34 (04): : 295 - 303
  • [42] Inhibition of VEGFR2 prevents DMBA-induced mammary tumor formation
    Heffelfinger, SC
    Yan, M
    Gear, RB
    Schneider, J
    LaDow, K
    Warshawsky, D
    LABORATORY INVESTIGATION, 2004, 84 (08) : 989 - 998
  • [43] INHIBITION OF DMBA-INDUCED MAMMARY-CANCER BY THE MONOTERPENE D-LIMONENE
    ELEGBEDE, JA
    ELSON, CE
    QURESHI, A
    TANNER, MA
    GOULD, MN
    PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 1984, 25 (MAR): : 127 - 127
  • [44] INHIBITION OF DMBA-INDUCED MAMMARY-CANCER BY THE MONOTERPENE D-LIMONENE
    ELEGBEDE, JA
    ELSON, CE
    QURESHI, A
    TANNER, MA
    GOULD, MN
    CARCINOGENESIS, 1984, 5 (05) : 661 - 664
  • [45] INHIBITORY EFFECT OF HUMAN URINARY EXTRACT ON THE GROWTH OF DMBA-INDUCED MAMMARY-TUMORS IN HOLTZMAN RAT
    SARKAR, S
    SHAH, PN
    BAGLI, NP
    NEOPLASMA, 1981, 28 (04) : 457 - 461
  • [46] EFFECT OF AN LHRH ANALOG ON GROWTH AND HORMONE RECEPTOR LEVELS IN DMBA-INDUCED MAMMARY-TUMORS IN THE RAT
    TURCOTLEMAY, L
    CUSAN, L
    SEGUIN, C
    KELLY, P
    LABRIE, F
    JOURNAL OF RECEPTOR RESEARCH, 1981, 2 (02): : 135 - 151
  • [47] BLOOD-FLOW AND REACTIVITY TO NORADRENALINE IN DMBA-INDUCED RAT MAMMARY NEOPLASIA
    WEISS, L
    HULTBORN, R
    CANCER LETTERS, 1980, 9 (04) : 293 - 298
  • [48] EFFECTS OF TAMOXIFEN, ESTRADIOL BENZOATE AND MEDROXYPROGESTERONE ACETATE ON THE GROWTH OF DMBA-INDUCED RAT MAMMARY-CARCINOMA
    ZANARDI, S
    DEMENECH, R
    PINO, G
    GUARNERI, D
    DANDOLO, G
    SANGUINETI, M
    MORO, MG
    BARBI, GP
    PAGANUZZI, M
    BOCCARDO, F
    CHEMIOTERAPIA, 1985, 4 (03): : 239 - 242
  • [49] GROWTH-INHIBITION OF DMBA-INDUCED RAT MAMMARY ADENOCARCINOMAS BY EXVIVO IMMUNOADSORPTION OF PLASMA WITH PROTEIN-A-CONTAINING STAPHYLOCOCCUS-AUREUS
    RAY, PK
    RAYCHAUDHURI, S
    MARK, R
    BASSETT, JG
    COOPER, DR
    PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 1981, 22 (MAR): : 283 - 283
  • [50] EFFECT OF OOPHORECTOMY ON PROGESTERONE METABOLISM IN DMBA-INDUCED MAMMARY-TUMORS OF THE RAT
    MORI, M
    TOMINAGA, T
    KITAMURA, M
    SAITO, T
    TAMAOKI, B
    EUROPEAN JOURNAL OF CANCER, 1980, 16 (10) : 1373 - 1375
12345