Growth inhibition of DMBA-induced rat mammary carcinomas by UK 114

被引：0
|
作者：
Silvia Racca
Francesco Di Carlo
Alberto Bartorelli
Benedetta Bussolati
G. Bussolati
机构：
[1] Department of Biological and Clinical Sciences,
[2] University of Turin,undefined
[3] Turin,undefined
[4] Italy,undefined
[5] ”G. Sisini” Institute,undefined
[6] University of Milan,undefined
[7] Milan,undefined
[8] Italy,undefined
[9] Department of Medical and Surgical Sciences,undefined
[10] University of Turin,undefined
[11] Turin,undefined
[12] Italy,undefined
[13] Department of Biomedical Sciences and Human Oncology,undefined
[14] University of Turin,undefined
[15] Via Santena 7,undefined
[16] I-10126 Torino,undefined
[17] Italy Tel.: (39) 11-6706505; Fax: (39) 11-6635267,undefined
来源：
Virchows Archiv | 1997年 / 431卷
关键词：
Key words Immunosurveillance; Cytotoxicity; Neoplasms; Dimethylbenzanthracene; Rats;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
 A perchloric acid-soluble protein extracted from goat liver and designated as UK 114 is known to be expressed over the cell membrane of (some) human cancer cell lines. This protein is antigenic, and specific antibodies elicit complement-dependent cytolysis of neoplastic target cells. In this study we demonstrate that administration of UK 114, either pure or as a crude extract (designated UK 101), inhibits the growth of mammary carcinomas induced in female Sprague-Dawley rats by dimethylbenzanthracene (DMBA). The mechanism of the tumour inhibitory activity of UK 114 is probably related to induction of immunosurveillance.
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页码：323 / 328
页数：5
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