Applications of brain organoids in neurodevelopment and neurological diseases

被引：0
作者：
Nan Sun
Xiangqi Meng
Yuxiang Liu
Dan Song
Chuanlu Jiang
Jinquan Cai
机构：
[1] The Second Affiliated Hospital of Harbin Medical University,Department of Neurosurgery
[2] Biomedicum,Department of Microbiology, Tumor and Cell Biology (MTC)
[3] Karolinska Institutet,undefined
来源：
Journal of Biomedical Science | / 28卷
关键词：
Brain organoid; Pluripotent stem cell; Brain development; Neurological disorders; Glioblastoma;
D O I：
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摘要：
A brain organoid is a self-organizing three-dimensional tissue derived from human embryonic stem cells or pluripotent stem cells and is able to simulate the architecture and functionality of the human brain. Brain organoid generation methods are abundant and continue to improve, and now, an in vivo vascularized brain organoid has been encouragingly reported. The combination of brain organoids with immune-staining and single-cell sequencing technology facilitates our understanding of brain organoids, including the structural organization and the diversity of cell types. Recent publications have reported that brain organoids can mimic the dynamic spatiotemporal process of early brain development, model various human brain disorders, and serve as an effective preclinical platform to test and guide personalized treatment. In this review, we introduce the current state of brain organoid differentiation strategies, summarize current progress and applications in the medical domain, and discuss the challenges and prospects of this promising technology.
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