Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells

被引：0

作者：

Markus Kleinewietfeld

Arndt Manzel

Jens Titze

Heda Kvakan

Nir Yosef

Ralf A. Linker

Dominik N. Muller

David A. Hafler

机构：

[1] Yale School of Medicine,Departments of Neurology and Immunobiology

[2] 15 York Street,Department of Neurology

[3] New Haven,Division of Clinical Pharmacology

[4] Connecticut 06520,Interdisciplinary Center for Clinical Research and Department for Nephrology and Hypertension

[5] USA,undefined

[6] Broad Institute of MIT and Harvard,undefined

[7] 7 Cambridge Center,undefined

[8] University of Erlangen-Nuremberg,undefined

[9] Schwabachanlage 6,undefined

[10] 91054 Erlangen,undefined

[11] Germany,undefined

[12] International Graduate School of Neuroscience,undefined

[13] Ruhr-University Bochum,undefined

[14] Universitätsstr. 150,undefined

[15] Vanderbilt University,undefined

[16] 2213 Garland Avenue,undefined

[17] Nashville,undefined

[18] Tennessee 37232,undefined

[19] USA,undefined

[20] University of Erlangen-Nuremberg,undefined

[21] Glückstr. 6,undefined

[22] 91054 Erlangen,undefined

[23] Germany,undefined

[24] Experimental and Clinical Research Center,undefined

[25] a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine,undefined

[26] Lindenberger Weg 80,undefined

[27] 13125 Berlin,undefined

[28] Germany,undefined

[29] Helios Klinikum Berlin-Buch,undefined

[30] Schwanebecker Chaussee 50,undefined

[31] 13125 Berlin,undefined

[32] Germany,undefined

[33] Nikolaus-Fiebiger-Center for Molecular Medicine,undefined

[34] University of Erlangen-Nuremberg,undefined

[35] Glückstr. 6,undefined

[36] 91054 Erlangen,undefined

[37] Germany,undefined

来源：

Nature | 2013年 / 496卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Increased salt concentrations are shown to induce murine and human TH17 cells by a mechanism that depends on activation of p38/MAPK, NFAT5 and SGK1; mice kept on a high-salt diet develop a more severe experimental autoimmune encephalomyelitis due to increased induction of TH17 cells.

引用

页码：518 / 522

页数：4

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