The heterogeneous biomechanics and mechanobiology of the mitral valve: Implications for tissue engineering

被引：33

作者：

Grande-Allen K.J. ^{[1
]}

Liao J. ^{[2
]}

机构：

[1] Department of Bioengineering, Rice University, MS 142, Houston, TX 77005

[2] Department of Biological Engineering, Mississippi State University, Mississippi State, MS 39762

来源：

Current Cardiology Reports | 2011年 / 13卷 / 2期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

Biomechanics; Chordae tendineae; Collagen; Congenital heart disease; Elastic modulus; Extracellular matrix; Glycosaminoglycans; Leaflets; Material behavior; Mechanobiology; Mitral regurgitation; Smooth muscle alpha-actin; Tissue engineering; Valvular endothelial cells; Valvular interstitial cells;

D O I：

10.1007/s11886-010-0161-2

中图分类号：

学科分类号：

摘要：

There are compelling reasons to develop a tissue-engineered mitral valve, but this endeavor has not received the same attention as tissue engineering strategies for the semilunar valves. Challenges in regenerating a mitral valve include recapitulating the complex heterogeneity in terms of anatomy (differently sized leaflets, numerous chordae), extracellular matrix composition, biomechanical behavior, valvular interstitial cell and endothelial cell phenotypes, and interior vasculature and innervation. It will also be essential to restore the functional relationships between the native mitral valve and left ventricle. A growing amount of information relevant to tissue engineering amitral valve has been recently collected through investigations of cell mechanobiology and collagen organization. It is hoped that the development of tissue-engineered mitral valves can build on knowledge derived from engineering semilunar valves, but the mitral valve will present its own unique challenges as investigators move toward a first-generation prototype. © Springer Science+Business Media, LLC 2011.

引用

页码：113 / 120

页数：7

共 51 条

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