IL-4 and IL-13 exposure during mucociliary differentiation of bronchial epithelial cells increases antimicrobial activity and expression of antimicrobial peptides

被引：0
作者：
Suzanne Zuyderduyn
Dennis K Ninaber
Jasmijn A Schrumpf
Marianne AJA van Sterkenburg
Renate M Verhoosel
Frans A Prins
Sandra van Wetering
Klaus F Rabe
Pieter S Hiemstra
机构：
[1] Leiden University Medical Center,Department of Pulmonology
[2] Leiden University Medical Center,Pathology
[3] DCPrime BV,undefined
来源：
Respiratory Research | / 12卷
关键词：
human; lung; cell differentiation; allergy; inflammation;
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摘要：
The airway epithelium forms a barrier against infection but also produces antimicrobial peptides (AMPs) and other inflammatory mediators to activate the immune system. It has been shown that in allergic disorders, Th2 cytokines may hamper the antimicrobial activity of the epithelium. However, the presence of Th2 cytokines also affects the composition of the epithelial layer which may alter its function. Therefore, we investigated whether exposure of human primary bronchial epithelial cells (PBEC) to Th2 cytokines during mucociliary differentiation affects expression of the human cathelicidin antimicrobial protein (hCAP18)/LL-37 and human beta defensins (hBD), and antimicrobial activity.
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  • [1] Van Wetering S(2000)Regulation of SLPI and elafin release from bronchial epithelial cells by neutrophil defensins Am J Physiol Lung Cell Mol Physiol 278 L51-L58
  • [2] van der Linden AC(2006)SLPI and elafin: one glove, many fingers Clin Sci (Lond) 110 21-35
  • [3] van Sterkenburg MA(1996)Antibacterial activity of antileukoprotease Infect Immun 64 4520-4524
  • [4] de Boer WI(2001)Adenoviral augmentation of elafin protects the lung against acute injury mediated by activated neutrophils and bacterial infection J Immunol 167 1778-1786
  • [5] Kuijpers AL(2002)Antimicrobial activity of antiproteinases Biochem Soc Trans 30 111-115
  • [6] Schalkwijk J(1997)Inhibition of human immunodeficiency virus type 1 infectivity by secretory leukocyte protease inhibitor occurs prior to viral reverse transcription Blood 90 1141-1149
  • [7] Williams SE(1993)Allergen exposure induces the activation of allergen-specific Th2 cells in the airway mucosa of patients with allergic respiratory disorders Eur J Immunol 23 1445-1449
  • [8] Brown TI(1992)Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma N Engl J Med 326 298-304
  • [9] Roghanian A(2007)Epithelial differentiation is a determinant in the production of eotaxin-2 and -3 by bronchial epithelial cells in response to IL-4 and IL-13 Mol Immunol 44 803-811
  • [10] Sallenave JM(1999)Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production J Clin Invest 103 779-788
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