Lead compounds for the development of SARS-CoV-2 3CL protease inhibitors (vol 12, 2016, 2021)

被引：4

作者：

Iketani, Sho

Forouhar, Farhad

Liu, Hengrui

Hong, Seo Jung

Lin, Fang-Yu

Nair, Manoj S.

Zask, Arie

Huang, Yaoxing

Xing, Li

Stockwell, Brent R.

Chavez, Alejandro

Ho, David D.

机构：

[1] Aaron Diamond AIDS Research Center, Columbia University Irving Medical Center, New York, NY

[2] Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY

[3] Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY

[4] Department of Chemistry, Columbia University, New York, NY

[5] Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY

[6] WuXi AppTec, Cambridge, MA

[7] Department of Biological Sciences, Columbia University, New York, NY

来源：

NATURE COMMUNICATIONS | 2021年 / 12卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/s41467-021-23082-3

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We report the identification of three structurally diverse compounds – compound 4, GC376, and MAC-5576 – as inhibitors of the SARS-CoV-2 3CL protease. Structures of each of these compounds in complex with the protease revealed strategies for further development, as well as general principles for designing SARS-CoV-2 3CL protease inhibitors. These compounds may therefore serve as leads for the basis of building effective SARS-CoV-2 3CL protease inhibitors. © 2021, The Author(s).

引用

页数：1

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