Endothelial metalloprotease-disintegrin protein (ADAM) is implicated in angiogenesis in vitro

被引：22
|
作者：
Trochon V. [1 ,2 ,7 ]
Li H. [2 ,3 ]
Vasse M. [2 ]
Frankenne F. [4 ]
Thomaidis A. [1 ]
Soria J. [5 ]
Lu H. [1 ]
Gardner C. [6 ]
Soria C. [1 ,2 ]
机构：
[1] Inserm U353, Institut d'Hématologie, Univ. Paris 7-Denis Diderot, F-75475 Paris Cedex 10
[2] Laboratoire DIFEMA, Fac. de Med. et de Pharm. de Rouen, Rouen
[3] Le Ctr. Natl. de la Rech. Sci., UMR 1582, Institut Gustave Roussy
[4] Lab. Biol. des Tumeurs et du Devmt., Liège
[5] Laboratoires Biochmie Sainte Marie, Hôtel Dieu, Paris
[6] HoechstMarion-Roussel, F-93235 Romainville
[7] INSERM U 353, Bat INSERM, Hôpital Saint Louis, F-75475, Paris Cedex 10
来源：
Angiogenesis | 1998年 / 2卷 / 3期
关键词：
ADAM/MDC; Angiogenesis; Endothelial cells;
D O I：
10.1023/A:1009206817829
中图分类号：
学科分类号：
摘要：
Recently two metalloproteinase, disintegrin, cysteine proteins (MDCs), also called ADAMs were identified on endothelial cells. However the role of these ADAMs are not defined on these cells. In order to elucidate whether ADAMs associated with endothelial cells could be involved in angiogenesis, we have tested the effect of an inhibitor of ADAM (GL 129471) in models of angiogenesis in vitro. Our results showed that GL 129471 inhibited endothelial cell migration and adhesion and increased the number of cells in the G2/M phase leading to an inhibition of cell proliferation. The effects of GL 129471 are not mimicked by the endogenous matrix metalloproteinase inhibitor TIMP-2. These data suggest that ADAMs may play important role in angiogenesis and could provide a new target for inhibition of angiogenesis in cancers.
引用
收藏
页码：277 / 285
页数：8
相关论文
共 50 条
  • [1] The metalloprotease-disintegrin ADAM8 contributes to temozolomide chemoresistance and enhanced invasiveness of human glioblastoma cells
    Dong, Fangyong
    Eibach, Michael
    Bartsch, Joerg W.
    Dolga, Amalia M.
    Schlomann, Uwe
    Conrad, Catharina
    Schieber, Susanne
    Schilling, Oliver
    Biniossek, Martin L.
    Culmsee, Carsten
    Strik, Herwig
    Koller, Garrit
    Carl, Barbara
    Nimsky, Christopher
    NEURO-ONCOLOGY, 2015, 17 (11) : 1474 - 1485
  • [2] A disintegrin and metalloprotease (ADAM) 33 protein in patients with pulmonary sarcoidosis
    Shaffiq, Asif
    Haitchi, Hans Michael
    Pang, Yun Yung
    Alangari, Abdullah A.
    Jones, Mark G.
    Marshall, Ben G.
    Howarth, Peter H.
    Davies, Donna E.
    O'Reilly, Katherine M. A.
    RESPIROLOGY, 2012, 17 (02) : 342 - 349
  • [3] A Disintegrin and Metalloprotease 15 is Expressed on Rheumatoid Arthritis Synovial Tissue Endothelial Cells and may Mediate Angiogenesis
    Nishimi, Shinichiro
    Isozaki, Takeo
    Wakabayashi, Kuninobu
    Takeuchi, Hiroko
    Kasama, Tsuyoshi
    CELLS, 2019, 8 (01)
  • [4] A Disintegrin and Metalloprotease 10 Is a Novel Mediator of Vascular Endothelial Growth Factor-Induced Endothelial Cell Function in Angiogenesis and Is Associated With Atherosclerosis
    Donners, M. P. C.
    Wolfs, Ine M. J.
    Olieslagers, Serve
    Mohammadi-Motahhari, Zeynab
    Tchaikovski, Vadim
    Heeneman, Sylvia
    van Buul, Jaap D.
    Caolo, Vincenza
    Molin, Daniel G. M.
    Post, Mark J.
    Waltenberger, Johannes
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2010, 30 (11) : 2188 - U382
  • [5] ADAM-17 regulates endothelial cell morphology, proliferation, and in vitro angiogenesis
    Goeoz, Pal
    Goeoz, Monika
    Baldys, Aleksander
    Hoffman, Stanley
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2009, 380 (01) : 33 - 38
  • [6] The soluble form of a disintegrin and metalloprotease 33 promotes angiogenesis: Implications for airway remodeling in asthma
    Puxeddu, Ilaria
    Pang, Yun Yun
    Harvey, Anna
    Haitchi, Hans Michael
    Nicholas, Ben
    Yoshisue, Hajime
    Ribatti, Domenico
    Clough, Geraldine
    Powell, Rob M.
    Murphy, Gillian
    Hanley, Neil A.
    Wilson, David I.
    Howarth, Peter H.
    Holgate, Stephen T.
    Davies, Donna E.
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2008, 121 (06) : 1400 - 1406
  • [7] A disintegrin and metalloprotease 12 promotes tumor progression by the inhibition of apoptosis and angiogenesis in the human colorectal cancer
    Park, Young-Lan
    Park, Sun-Young
    Myung, Dae-Seong
    Kim, Hyun-Soo
    Joo, Young-Eun
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2018, 33 : 449 - 449
  • [8] A disintegrin and metalloprotease 10-containing exosomes derived from nasal polyps promote angiogenesis and vascular permeability
    Zhang, Wei
    Zhang, Jie
    Cheng, Lei
    Ni, Haosheng
    You, Bo
    Shan, Ying
    Bao, Lili
    Wu, Di
    Zhang, Ting
    Yue, Huijun
    Chen, Jing
    MOLECULAR MEDICINE REPORTS, 2018, 17 (04) : 5921 - 5927
  • [9] Mast Cells Interact with Endothelial Cells to Accelerate In Vitro Angiogenesis
    de Souza Junior, Devandir Antonio
    Mazucato, Vivian Marino
    Santana, Ana Carolina
    Oliver, Constance
    Jamur, Maria Celia
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (12)
  • [10] Formation of the Collateral Circulation Is Regulated by Vascular Endothelial Growth Factor-A and A Disintegrin and Metalloprotease Family Members 10 and 17
    Lucitti, Jennifer L.
    Mackey, Jessica K.
    Morrison, Jeffrey C.
    Haigh, Jody J.
    Adams, Ralf H.
    Faber, James E.
    CIRCULATION RESEARCH, 2012, 111 (12) : 1539 - +
12345