Thermal stability of ketoprofen—active substance and tabletsPart 1. Kinetic study of the active substance under non-isothermal conditions

Simultaneous thermoanalytical techniques were used for the characterization of the thermal decomposition of ketoprofen—active substance and tablets. DTA and DSC curves showed that ketoprofen melts before the decomposition. A kinetic study regarding the ketoprofen—active substance’s thermal decomposition was performed under non-isothermal conditions and in a nitrogen atmosphere at five heating rates: 2.5, 5, 7.5, 10 and 15 °C min−1. The kinetic parameters of thermal decomposition process were obtained from TG/DTG curves using the following differential methods: Friedman isoconversional, Chang, respectively, integral methods: Flynn–Wall–Ozawa, Kissinger–Akahira–Sunose, Coats–Redfern and Madhusudanan. The careful treatment of the kinetic parameters obtained in certain thermal conditions was confirmed to be necessary as well as a different strategy of experimental data processing.