Wound healing evaluation of benzalkonium chloride-loaded hydrocolloid in the wound infection model

被引：10
作者：
Kim J.H. [1 ]
Jin S.G. [2 ]
Ku S.K. [3 ]
Nam D.H. [1 ]
Sohn Y.T. [4 ]
Ryu D.S. [2 ]
Do E.-S. [2 ]
Jang S.W. [2 ]
Son M.W. [2 ]
Yong C.S. [1 ]
Choi H.-G. [5 ]
Kim J.O. [1 ]
机构：
[1] College of Pharmacy, Yeungnam University, Gyeongsan, 712-749, 214-1, Dae-Dong
[2] Pharmaceutical Product Research Laboratories, Dong-A Pharmaceutical Co. Ltd., Kyunggi-Do, Yongin-Si
[3] College of Oriental Medicine, Daegu Haany University, Gyeongsan
[4] College of Pharmacy, Duksung Women's University, Seoul
[5] College of Pharmacy, Hanyang University, Ansan, 426-791, 1271
来源：
Journal of Pharmaceutical Investigation | 2012年 / 42卷 / 6期
基金：
新加坡国家研究基金会;
关键词：
Benzalkonium chloride; Hydrocolloid; Wound dressing; Wound healing;
D O I：
10.1007/s40005-012-0043-2
中图分类号：
学科分类号：
摘要：
An adequate environment for wound healing improves cell proliferation and cell activity, rearranges fibroblasts, and suppresses the multiplication of bacteria. The aim of this study was to evaluate the wound-healing effects of a semi-occlusive hydrocolloid wound dressing (HWD) containing a topical antiseptic drug, benzalkonium chloride (BKC) in an infectious wound model. In vivo wound-healing profiles in rats exhibited that BKC-loaded HWD successfully promoted epithelialization rate, compared with gauze control or HWD without BKC. Furthermore, the significant decrease in desquamated epithelial regions, numbers of microvessels and inflammatory cells infiltrated in granulation tissues and granulation tissue areas were observed in the histopathological and histomorphometrical profiles of BKC-loaded HWD. In conclusion, these results suggest that BKC-loaded HWD facilitates wound healing and re-epithelization, and has promising effects for the treatment of infected wounds, as compared to HWD without BKC. © 2012 The Korean Society of Pharmaceutical Sciences and Technology.
引用
收藏
页码：327 / 333
页数：6
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