Lymphatic Tissue Engineering and Regeneration

被引：0
作者：
Laura Alderfer
Alicia Wei
Donny Hanjaya-Putra
机构：
[1] University of Notre Dame,Department of Aerospace and Mechanical Engineering, Bioengineering Graduate Program
[2] University of Notre Dame,Department of Chemical and Biomolecular Engineering
[3] University of Notre Dame,Harper Cancer Research Institute
[4] University of Notre Dame,Center for Stem Cells and Regenerative Medicine
[5] University of Notre Dame,Advanced Diagnostics and Therapeutics
[6] University of Notre Dame,Center for Nanoscience and Technology (NDnano)
来源：
Journal of Biological Engineering | / 12卷
关键词：
Lymphangiogenesis; Tissue Engineering; Disease Modeling; Wound Healing; Lymphedema; Stem Cells; Biomaterials; Interstitial Fluid; Regeneration;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The lymphatic system is a major circulatory system within the body, responsible for the transport of interstitial fluid, waste products, immune cells, and proteins. Compared to other physiological systems, the molecular mechanisms and underlying disease pathology largely remain to be understood which has hindered advancements in therapeutic options for lymphatic disorders. Dysfunction of the lymphatic system is associated with a wide range of disease phenotypes and has also been speculated as a route to rescue healthy phenotypes in areas including cardiovascular disease, metabolic syndrome, and neurological conditions. This review will discuss lymphatic system functions and structure, cell sources for regenerating lymphatic vessels, current approaches for engineering lymphatic vessels, and specific therapeutic areas that would benefit from advances in lymphatic tissue engineering and regeneration.
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