Role of the metabotropic glutamate receptor subtype 1 in the Harmaline-induced tremor in rats

被引：0
作者：
Wacław Kolasiewicz
Katarzyna Kuter
Jadwiga Wardas
Krystyna Ossowska
机构：
[1] Institute of Pharmacology,Department of Neuro
[2] Polish Academy of Sciences,Psychopharmacology
来源：
Journal of Neural Transmission | 2009年 / 116卷
关键词：
Tremor; Harmaline; Glutamate metabotropic receptor subtype 1; Cerebellum; Rat;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The present study shows that JNJ 16259685—a selective antagonist of glutamate metabotropic receptor subtype 1 (mGluR1) injected in doses of 0.16 and 0.32 mg/kg sc strongly enhances tremor of forelimbs, head and trunk, hypolocomotion, and ataxia induced by harmaline (7.5 mg/kg ip) in rats. JNJ 16259685 inhibited locomotor and exploratory activity per se. These results may suggest an inhibitory influence of mGluR1 on the harmaline-induced motor disturbances.
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页码：1059 / 1063
页数：4
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