Role of the metabotropic glutamate receptor subtype 1 in the Harmaline-induced tremor in rats

被引：0
作者：
Wacław Kolasiewicz
Katarzyna Kuter
Jadwiga Wardas
Krystyna Ossowska
机构：
[1] Institute of Pharmacology,Department of Neuro
[2] Polish Academy of Sciences,Psychopharmacology
来源：
Journal of Neural Transmission | 2009年 / 116卷
关键词：
Tremor; Harmaline; Glutamate metabotropic receptor subtype 1; Cerebellum; Rat;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The present study shows that JNJ 16259685—a selective antagonist of glutamate metabotropic receptor subtype 1 (mGluR1) injected in doses of 0.16 and 0.32 mg/kg sc strongly enhances tremor of forelimbs, head and trunk, hypolocomotion, and ataxia induced by harmaline (7.5 mg/kg ip) in rats. JNJ 16259685 inhibited locomotor and exploratory activity per se. These results may suggest an inhibitory influence of mGluR1 on the harmaline-induced motor disturbances.
引用
收藏
页码：1059 / 1063
页数：4
相关论文
共 50 条
  • [31] 6-OHDA injections into A8-A9 dopaminergic neurons modelling early stages of Parkinson's disease increase the harmaline-induced tremor in rats
    Kolasiewicz, Waclaw
    Kuter, Katarzyna
    Berghauzen, Klemencja
    Nowak, Przemyslaw
    Schulze, Gert
    Ossowska, Krystyna
    BRAIN RESEARCH, 2012, 1477 : 59 - 73
  • [32] Concurrent quantification of tremor and depression of locomotor activity induced in rats by harmaline and physostigmine
    Wang, GH
    Fowler, SC
    PSYCHOPHARMACOLOGY, 2001, 158 (03) : 273 - 280
  • [33] Effect of acute caffeine on severity of harmaline induced tremor in rats
    Al Deeb, S
    Al Moutaery, K
    Arshaduddin, M
    Biary, N
    Tariq, M
    NEUROSCIENCE LETTERS, 2002, 325 (03) : 216 - 218
  • [34] A partial lesion of the substantia nigra pars compacta and retrorubral field decreases the harmaline-induced glutamate release in the rat cerebellum
    Golembiowska, Krystyna
    Berghauzen-Maciejewska, Klemencja
    Gorska, Anna
    Kaminska, Katarzyna
    Ossowska, Krystyna
    BRAIN RESEARCH, 2013, 1537 : 303 - 311
  • [35] HARMALINE-INDUCED AMNESIA: POSSIBLE ROLE OF THE AMYGDALA DOPAMINERGIC SYSTEM
    Nasehi, M.
    Meskarian, M.
    Khakpai, F.
    Zarrindast, M. -R.
    NEUROSCIENCE, 2016, 312 : 1 - 9
  • [36] A Role for GABAA Receptor β3 Subunits in Mediating Harmaline Tremor Suppression by Alcohol: Implications for Essential Tremor Therapy
    Handforth, Adrian
    Singh, Ram P.
    Kosoyan, Hovsep P.
    Kadam, Pournima A.
    TREMOR AND OTHER HYPERKINETIC MOVEMENTS, 2024, 14
  • [37] Lacosamide, the new anticonvulsant, effectively reduces harmaline-induced tremors in rats
    Stoehr, Thomas
    Lekieffre, Delphine
    Freitag, Joachim
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2008, 589 (1-3) : 114 - 116
  • [38] Low-dose acute vanillin is beneficial against harmaline-induced tremors in rats
    Abdulrahman, Al Asmari
    Faisal, Kunnathodi
    Meshref, Ali Al Amri
    Arshaduddin, Mohammed
    NEUROLOGICAL RESEARCH, 2017, 39 (03) : 264 - 270
  • [39] Peroxisome proliferator-activated receptor-γ activation attenuates harmaline-induced cognitive impairments in rats
    Aghaei, Iraj
    Hajali, Vahid
    Haghani, Masoud
    Vaziri, Zohreh
    Moosazadeh, Mahmmod
    Shabani, Mohammad
    JOURNAL OF CLINICAL NEUROSCIENCE, 2019, 59 : 276 - 283
  • [40] Phytohormone abscisic acid elicits positive effects on harmaline-induced cognitive and motor disturbances in a rat model of essential tremor
    Shabani, Mohammad
    Naderi, Reyhaneh
    BRAIN AND BEHAVIOR, 2022, 12 (05):
12345