Role of the metabotropic glutamate receptor subtype 1 in the Harmaline-induced tremor in rats

被引：0
|
作者：
Wacław Kolasiewicz
Katarzyna Kuter
Jadwiga Wardas
Krystyna Ossowska
机构：
[1] Institute of Pharmacology,Department of Neuro
[2] Polish Academy of Sciences,Psychopharmacology
来源：
Journal of Neural Transmission | 2009年 / 116卷
关键词：
Tremor; Harmaline; Glutamate metabotropic receptor subtype 1; Cerebellum; Rat;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The present study shows that JNJ 16259685—a selective antagonist of glutamate metabotropic receptor subtype 1 (mGluR1) injected in doses of 0.16 and 0.32 mg/kg sc strongly enhances tremor of forelimbs, head and trunk, hypolocomotion, and ataxia induced by harmaline (7.5 mg/kg ip) in rats. JNJ 16259685 inhibited locomotor and exploratory activity per se. These results may suggest an inhibitory influence of mGluR1 on the harmaline-induced motor disturbances.
引用
收藏
页码：1059 / 1063
页数：4
相关论文
共 50 条
  • [1] Role of the metabotropic glutamate receptor subtype 1 in the Harmaline-induced tremor in rats
    Kolasiewicz, Waclaw
    Kuter, Katarzyna
    Wardas, Jadwiga
    Ossowska, Krystyna
    JOURNAL OF NEURAL TRANSMISSION, 2009, 116 (09) : 1059 - 1063
  • [2] Apomorphine enhances harmaline-induced tremor in rats
    Ossowska, Krystyna
    Glowacka, Urszula
    Kosmowska, Barbara
    Wardas, Jadwiga
    PHARMACOLOGICAL REPORTS, 2015, 67 (03) : 435 - 441
  • [3] Apomorphine enhances harmaline-induced tremor in rats
    Krystyna Ossowska
    Urszula Głowacka
    Barbara Kosmowska
    Jadwiga Wardas
    Pharmacological Reports, 2015, 67 : 435 - 441
  • [4] Lesion of the Cerebellar Noradrenergic Innervation Enhances the Harmaline-Induced Tremor in Rats
    Kolasiewicz, Waclaw
    Kuter, Katarzyna
    Nowak, Przemyslaw
    Pastuszka, Agnieszka
    Ossowska, Krystyna
    CEREBELLUM, 2011, 10 (02) : 267 - 280
  • [5] Lesion of the Cerebellar Noradrenergic Innervation Enhances the Harmaline-Induced Tremor in Rats
    Wacław Kolasiewicz
    Katarzyna Kuter
    Przemysław Nowak
    Agnieszka Pastuszka
    Krystyna Ossowska
    The Cerebellum, 2011, 10 : 267 - 280
  • [6] Exacerbation of harmaline-induced tremor by imipramine
    Arshaduddin, M
    Kadasah, S
    Al Deeb, S
    Al Moutaery, K
    Tariq, M
    PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2005, 81 (01) : 9 - 14
  • [7] Riluzole Ameliorates Harmaline-induced Tremor in Rat
    Shourmasti, Fatemeh Rahimi
    Goudarzi, Iran
    Abrari, Kataneh
    Salmani, Mahmoud Elahdadi
    Laskarbolouki, Taghi
    BASIC AND CLINICAL NEUROSCIENCE, 2014, 5 (02) : 138 - 143
  • [8] Suppression of harmaline-induced tremor in rats by vagus nerve stimulation
    Handforth, A
    Krahl, SE
    MOVEMENT DISORDERS, 2001, 16 (01) : 84 - 88
  • [9] Development of Harmaline-induced Tremor in a Swine Model
    Lee, Jihyun
    Kim, Inyong
    Lee, Jeyeon
    Knight, Emily
    Cheng, Lei
    Kang, Shin Il
    Jang, Dong Pyo
    Chang, Su-Youne
    TREMOR AND OTHER HYPERKINETIC MOVEMENTS, 2018, 8
  • [10] Effects of unilateral stereotactic posterior striatotomy on harmaline-induced tremor in rats
    Vilela-Filho, Osvaldo
    Ferraz, Fernando P.
    Barros, Breno A.
    Silva, Luciana O.
    Anunciacao, Suzana F.
    Souza, Joaquim T.
    Silva, Delson J.
    Leite, Mauricio B.
    Atayde, Ingrid B.
    Ragazzo, Paulo C.
    Barreto, Paula G.
    Nobrega, Mariana A.
    Araujo, Maisa R.
    Santos, Mayra R.
    Ala, Victor H.
    Queiroz, Stefano T.
    JOURNAL OF NEUROSCIENCE RESEARCH, 2013, 91 (10) : 1328 - 1337
12345