Endothelial Shear Stress and Blood Viscosity in Peripheral Arterial Disease

被引：0
作者：
Young I. Cho
Daniel J. Cho
Robert S. Rosenson
机构：
[1] Drexel University,Department of Mechanical Eng. and Mechanics
[2] Rheovector,Mount Sinai Heart
[3] LLC,undefined
[4] Icahn School of Medicine at Mount Sinai,undefined
来源：
Current Atherosclerosis Reports | 2014年 / 16卷
关键词：
Endothelial shear stress; Blood viscosity; Peripheral arterial disease; Tortuosity; Curvature; Intermittent claudication; Critical limb ischemia; Hemodilution; Cilostazol; Pentoxifylline; Chylomicrons; VLDL; LDL; Hyperviscosity; Pain-free walking distance;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
This review examines the emerging role of endothelial shear stress (ESS) and blood viscosity on the initiation and progression of atherosclerosis in peripheral arterial disease. Among the variables determining ESS, blood viscosity has to date been the most overlooked by clinical researchers. Blood viscosity is a laboratory assessment that is minimally invasive and modifiable using pharmacologic therapy as well as by hemodilution. Monitoring and controlling blood viscosity not only modulates ESS, but also reduces peripheral vascular resistance and increases blood flow to the lower extremities.
引用
收藏
相关论文
共 50 条
  • [41] Lipid apheresis and rheopheresis for treatment of peripheral arterial disease
    Weiss, N.
    ATHEROSCLEROSIS SUPPLEMENTS, 2009, 10 (05) : 62 - 69
  • [42] Peripheral arterial disease - Management of peripheral arterial disease in the elderly
    Aronow, Wilbert S.
    GERIATRICS-US, 2007, 62 (01): : 19 - 25
  • [43] Wall morphology, blood flow and wall shear stress: MR findings in patients with peripheral artery disease
    Mauricio S. Galizia
    Alex Barker
    Yihua Liao
    Jeremy Collins
    James Carr
    Mary M. McDermott
    Michael Markl
    European Radiology, 2014, 24 : 850 - 856
  • [44] Use of hyperspectral imaging to assess endothelial dysfunction in peripheral arterial disease
    Sumpio, Brandon J.
    Citoni, Gianluca
    Chin, Jason A.
    Sumpio, Bauer E.
    JOURNAL OF VASCULAR SURGERY, 2016, 64 (04) : 1066 - 1073
  • [45] ENDOTHELIAL DYSFUNCTION MEASURED IN THE LOWER EXTREMITIES OF PATIENTS WITH PERIPHERAL ARTERIAL DISEASE
    Medina-Maldonado, F. J.
    Martinez-Aguilar, E.
    de Haro-Miralles, J.
    Florez-Gonzalez, A.
    March-Garcia, J. R.
    Acin, F.
    ANGIOLOGIA, 2007, 59 (03): : 237 - 244
  • [46] Relationship Between Noninvasively Measured Endothelial Function and Peripheral Arterial Disease
    Medina Maldonado, Francisco Jose
    de Haro Miralles, Joaquin
    Martinez Aguilar, Esther
    Florez Gonzalez, Aurora
    March Garcia, Jose Ramon
    Acin Garcia, Francisco
    ANGIOLOGY, 2009, 60 (06) : 725 - 731
  • [47] Endothelial dysfunction: A key to the pathophysiology and natural history of peripheral arterial disease?
    Brevetti, Gregorio
    Schiano, Vittorio
    Chiariello, Massimo
    ATHEROSCLEROSIS, 2008, 197 (01) : 1 - 11
  • [48] Endothelial progenitor cells and their potential clinical applications in peripheral arterial disease
    Alobaid, N
    Alnaeb, ME
    Sales, KM
    Seifalian, AM
    Mikhailidis, DP
    Hamilton, G
    ENDOTHELIUM-JOURNAL OF ENDOTHELIAL CELL RESEARCH, 2005, 12 (5-6): : 243 - 250
  • [49] Wall morphology, blood flow and wall shear stress: MR findings in patients with peripheral artery disease
    Galizia, Mauricio S.
    Barker, Alex
    Liao, Yihua
    Collins, Jeremy
    Carr, James
    McDermott, Mary M.
    Markl, Michael
    EUROPEAN RADIOLOGY, 2014, 24 (04) : 850 - 856
  • [50] The Forgotten Variable of Shear Stress in Mitral Annular Calcification: Whole Blood Viscosity
    Cetin, Elif Hande Ozcan
    Cetin, Mehmet Serkan
    Canpolat, Ugur
    Kalender, Erol
    Topaloglu, Serkan
    Aras, Dursun
    Aydogdu, Sinan
    MEDICAL PRINCIPLES AND PRACTICE, 2015, 24 (05) : 444 - 450
12345