Endothelial Shear Stress and Blood Viscosity in Peripheral Arterial Disease

被引：0
作者：
Young I. Cho
Daniel J. Cho
Robert S. Rosenson
机构：
[1] Drexel University,Department of Mechanical Eng. and Mechanics
[2] Rheovector,Mount Sinai Heart
[3] LLC,undefined
[4] Icahn School of Medicine at Mount Sinai,undefined
来源：
Current Atherosclerosis Reports | 2014年 / 16卷
关键词：
Endothelial shear stress; Blood viscosity; Peripheral arterial disease; Tortuosity; Curvature; Intermittent claudication; Critical limb ischemia; Hemodilution; Cilostazol; Pentoxifylline; Chylomicrons; VLDL; LDL; Hyperviscosity; Pain-free walking distance;
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学科分类号：
摘要：
This review examines the emerging role of endothelial shear stress (ESS) and blood viscosity on the initiation and progression of atherosclerosis in peripheral arterial disease. Among the variables determining ESS, blood viscosity has to date been the most overlooked by clinical researchers. Blood viscosity is a laboratory assessment that is minimally invasive and modifiable using pharmacologic therapy as well as by hemodilution. Monitoring and controlling blood viscosity not only modulates ESS, but also reduces peripheral vascular resistance and increases blood flow to the lower extremities.
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