Essential function for SWI-SNF chromatin-remodeling complexes in the promoter-directed assembly of Tcrb genes

被引：0
作者：
Oleg Osipovich
Robin Milley Cobb
Kenneth J Oestreich
Steven Pierce
Pierre Ferrier
Eugene M Oltz
机构：
[1] Vanderbilt University,Department of Microbiology and Immunology
[2] Centre d'Immunologie de Marseille-Luminy,undefined
[3] Institut National de la Santé et de la Recherche Médicale–Centre National de la Recherche Scientifique,undefined
[4] Université de la Méditerranée,undefined
[5] Marseille,undefined
[6] Present address: Rollins Research Center,undefined
[7] Emory University,undefined
[8] Atlanta,undefined
[9] Georgia 30322,undefined
[10] USA.,undefined
来源：
Nature Immunology | 2007年 / 8卷
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摘要：
The assembly of genes encoding antigen receptors is regulated by developmental changes in chromatin that either permit or deny access to a single variable-(diversity)-joining recombinase. These changes are guided by transcriptional promoters and enhancers, which serve as accessibility-control elements in antigen-receptor loci. The function of each accessibility-control element and the factors they recruit to remodel chromatin remain obscure. Here we show that the recruitment of SWI-SNF chromatin-remodeling complexes compensated for the accessibility-control element function of a promoter but not an enhancer of the T cell receptor-β locus (Tcrb). Loss of SWI-SNF function in thymocytes inactivated recombinase targets at the endogenous Tcrb locus. Thus, initiation of Tcrb gene assembly and T cell development is contingent on the recruitment of SWI-SNF to promoters, which exposes gene segments to variable-(diversity)-joining recombinase.
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页码：809 / 816
页数：7
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