Exosomes for targeting KRAS in the treatment of pancreatic cancer

被引：0
|
作者：
Louis Buscail
机构：
[1] Centre of Clinical Investigation for Biotherapy and INSERM U1037,Department of Gastroenterology
[2] Rangueil Hospital,undefined
[3] Centre Hospitalier Universitaire of Toulouse and University of Toulouse 3,undefined
来源：
Nature Reviews Gastroenterology & Hepatology | 2017年 / 14卷
关键词：
D O I：
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学科分类号：
摘要：
KRAS oncogene mutations are commonly encountered in pancreatic ductal adenocarcinoma, driving tumour initiation, proliferation, progression and metastasis. Human exosomes engineered to deliver small interfering RNA silencing KRASG12D are highly efficient at specifically targeting pancreatic cancer cells to dramatically reduce RAS activation, cancer cell proliferation and metastatic processes.
引用
收藏
页码：636 / 638
页数：2
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