Coexistence of treatment-related MLL cleavage and rearrangement in a child with haemophagocytic lymphohistiocytosis

被引：0
作者：
A Ng
P F Ravetto
G M Taylor
R F Wynn
O B Eden
机构：
[1] Immunogenetics Laboratory,Department of Paediatric Haematology
[2] University of Manchester,undefined
[3] Central Manchester and Manchester Children's University Hospitals Trust,undefined
[4] Academic Unit of Paediatric Oncology,undefined
[5] Central Manchester and Manchester Children's University Hospitals Trust,undefined
[6] Central Manchester and Manchester Children's University Hospitals Trust,undefined
来源：
British Journal of Cancer | 2004年 / 91卷
关键词：
treatment-related leukaemia; cleavage and rearrangement; HLH;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Treatment-related acute myeloid leukaemia (t-AML) is a serious complication of topoisomerase 2 inhibitor therapy and is characterised by the presence of mixed lineage leukaemia (MLL) rearrangement. By molecular tracking, we were able to show that MLL cleavage preceded gene rearrangement by 3 months and before the clinical diagnosis of t-AML in a patient with haemophagocytic lymphohistiocytosis. This is the first report on the sequential detection of the two biomarkers in treatment-related leukaemogenesis.
引用
收藏
页码：1990 / 1992
页数：2
相关论文
共 63 条
  • [1] Aplan PD(1996)Site-specific DNA cleavage within the Blood 87 2649-2658
  • [2] Chervinsky DS(1998) breakpoint cluster region induced by topoisomerase 2 inhibitors Biochim Biophys Acta 1400 233-255
  • [3] Stanulla M(1998)Secondary leukaemias induced by topoisomerase-targeted drugs Leukemia 12 976-981
  • [4] Burhans WC(1997)Panhandle PCR: a technical advance to amplify Med Pediatr Oncol 28 342-347
  • [5] Felix CA(2001) genomic translocation breakpoints Med Pediatr Oncol 37 153-154
  • [6] Felix CA(2001)HLH-94: a treatment protocol for hemophagocytic lymphohistiocytosis Proc Natl Acad Sci USA 98 9802-9807
  • [7] Jones DH(2000)Secondary acute myelocytic leukemia after successful chemotherapy with etoposide for Epstein–Barr virus-associated hemophagocytic lymphohistiocytosis Proc Natl Acad Sci USA 97 2814-2819
  • [8] Henter JI(2002)Near-precise interchromosomal recombination and functional DNA topoisomerase 2 cleavage sites at Br J Haematol 109 13-23
  • [9] Arico M(1998) and Br J Haematol 101 130-140
  • [10] Egeler RM(1998) genomic breakpoints in treatment-related acute lymphoblastic leukemia with t(4;11) translocation Int J Hematol 68 333-336
1234567