Predictive factors for surgical treatment in preterm neonates with necrotizing enterocolitis: a multicenter case-control study

被引：0
作者：
Sofia el Manouni el Hassani
Hendrik J. Niemarkt
Joep P. M. Derikx
Daniel J. C. Berkhout
Andrea E. Ballón
Margot de Graaf
Willem P. de Boode
Veerle Cossey
Christian V. Hulzebos
Anton H. van Kaam
Boris W. Kramer
Richard A. van Lingen
Daniel C. Vijlbrief
Mirjam M. van Weissenbruch
Marc A. Benninga
Nanne K. H. de Boer
Tim G. J. de Meij
机构：
[1] Amsterdam UMC,Department of Pediatric Gastroenterology
[2] Academic Medical Center,Department of Pediatric Gastroenterology
[3] Amsterdam UMC,Neonatal Intensive Care Unit
[4] VU University Medical Center,Department of Pediatric Surgery
[5] Máxima Medical Center,Neonatal Intensive Care Unit
[6] Emma Children’s Hospital,Neonatal Intensive Care Unit
[7] Amsterdam UMC,Neonatal Intensive Care Unit
[8] University of Amsterdam and Vrije Universiteit,Neonatal Intensive Care Unit
[9] Radboud University Medical Center,Neonatal Intensive Care Unit
[10] Radboud Institute for Health Sciences,Department of Pediatrics
[11] Amalia Children’s Hospital,Neonatal Intensive Care Unit
[12] University Hospitals Leuven,Neonatal Intensive Care Unit
[13] Beatrix Children’s Hospital,Department of Gastroenterology and Hepatology
[14] University Medical Center Groningen,undefined
[15] Amsterdam UMC,undefined
[16] VU University Medical Center,undefined
[17] Amsterdam UMC,undefined
[18] Academic Medical Center,undefined
[19] Maastricht University Medical Center,undefined
[20] Amalia Children’s Center/Isala,undefined
[21] Wilhelmina Children’s Hospital/University Medical Center Utrecht,undefined
[22] Utrecht University,undefined
[23] Amsterdam Gastroenterology and Metabolism Research Institute,undefined
[24] Amsterdam UMC,undefined
[25] Vrije Universiteit Amsterdam,undefined
来源：
European Journal of Pediatrics | 2021年 / 180卷
关键词：
Risk factors; Surgery; Prediction; Necrotizing enterocolitis;
D O I：
暂无
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学科分类号：
摘要：
Necrotizing enterocolitis (NEC) is one of the most common and lethal gastrointestinal diseases in preterm infants. Early recognition of infants in need for surgical intervention might enable early intervention. In this multicenter case-control study, performed in nine neonatal intensive care units, preterm born infants (< 30 weeks of gestation) diagnosed with NEC (stage ≥ IIA) between October 2014 and August 2017 were divided into two groups: (1) medical (conservative treatment) and (2) surgical NEC (sNEC). Perinatal, clinical, and laboratory parameters were collected daily up to clinical onset of NEC. Univariate and multivariate logistic regression analyses were applied to identify potential predictors for sNEC. In total, 73 preterm infants with NEC (41 surgical and 32 medical NEC) were included. A low gestational age (p value, adjusted odds ratio [95%CI]; 0.001, 0.91 [0.86–0.96]), no maternal corticosteroid administration (0.025, 0.19 [0.04–0.82]), early onset of NEC (0.003, 0.85 [0.77–0.95]), low serum bicarbonate (0.009, 0.85 [0.76–0.96]), and a hemodynamically significant patent ductus arteriosus for which ibuprofen was administered (0.003, 7.60 [2.03–28.47]) were identified as independent risk factors for sNEC.
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页码：617 / 625
页数：8
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