MyD88 in Mycobacterium tuberculosis infection

被引：0
作者：
Jorge L. Cervantes
机构：
[1] Texas Tech University Health Sciences Center El Paso,Paul L. Foster School of Medicine
来源：
Medical Microbiology and Immunology | 2017年 / 206卷
关键词：
MyD88; Phagosome; Regulation of inflammation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
MyD88 adaptor protein mediates numerous biologically important signal transduction pathways in innate immunity. MyD88 signaling fosters bacterial containment and is necessary to raise an adequate innate and acquired immune response to Mycobacterium tuberculosis (Mtb). The phagosome is a crucial cellular location not only for Mtb replication, but it is also where components of the Myddosome and inflammasome are recruited. Besides its function as a TLR-adaptor protein, MyD88 may help stabilizing cytosolic receptors that are recruited to the phagosome. MyD88 plays a critical role not only in the generation of an inflammatory response, but also in inducing regulatory signals to prevent excessive inflammation and cellular damage in the lung.
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页码：187 / 193
页数：6
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[1]  
Kawai T(2010)The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors Nat Immunol 11 373-384
[2]  
Akira S(1997)A human homologue of the Drosophila Toll protein signals activation of adaptive immunity Nature 388 394-397
[3]  
Medzhitov R(1999)Unresponsiveness of MyD88-deficient mice to endotoxin Immunity 11 115-122
[4]  
Preston-Hurlburt P(1990)Nucleotide sequence and expression of a cDNA encoding MyD88, a novel myeloid differentiation primary response gene induced by IL6 Oncogene 5 1095-1097
[5]  
Janeway CA(1997)IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling Science 278 1612-1615
[6]  
Kawai T(1997)MyD88: an adapter that recruits IRAK to the IL-1 receptor complex Immunity 7 837-847
[7]  
Adachi O(1994)Macrophage differentiation marker MyD88 is a member of the Toll/IL-1 receptor family Biochem Biophys Res Commun 199 144-146
[8]  
Ogawa T(2013)MyD88: a critical adaptor protein in innate immunity signal transduction J Immunol 190 3-4
[9]  
Takeda K(2014)Toll-Like Receptors and Cancer: MYD88 Mutation and Inflammation Front Immunol 5 367-3135
[10]  
Akira S(2012)Experimental and natural infections in MyD88- and IRAK-4-deficient mice and humans Eur J Immunol 42 3126-696
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