Synaptic activation of kainate receptors gates presynaptic CB1 signaling at GABAergic synapses

被引:0
作者
Joana Lourenço
Astrid Cannich
Mario Carta
Françoise Coussen
Christophe Mulle
Giovanni Marsicano
机构
[1] INSERM U862 NeuroCentre Magendie,
[2] Endocannabinoids and Neuroadaptation,undefined
[3] PhD Programme in Experimental Biology and Biomedicine,undefined
[4] Center for Neuroscience and Cell Biology,undefined
[5] University of Coimbra,undefined
[6] Laboratoire Physiologie Cellulaire de la Synapse,undefined
[7] Centre National de la Recherche Scientifique UMR 5091,undefined
[8] University of Bordeaux,undefined
来源
Nature Neuroscience | 2010年 / 13卷
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摘要
Glutamate-induced kainate receptor activation can inhibit or facilitate inhibitory synaptic transmission. This study demonstrates that it is the concerted activity of presynaptic CB1 receptors and kainate receptors that together mediate short-term depression of inhibitory synaptic transmission.
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页码:197 / 204
页数:7
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[1]  
Lerma J(2006)Kainate receptor physiology Curr. Opin. Pharmacol. 6 89-97
[2]  
Pinheiro P(2006)Kainate receptors Cell Tissue Res. 326 457-482
[3]  
Mulle C(1999)Synaptically released glutamate reduces gamma-aminobutyric acid (GABA)ergic inhibition in the hippocampus via kainate receptors Proc. Natl. Acad. Sci. USA 96 9932-9937
[4]  
Min MY(2001)A kainate receptor increases the efficacy of GABAergic synapses Neuron 30 503-513
[5]  
Melyan Z(2003)The molecular logic of endocannabinoid signaling Nat. Rev. Neurosci. 4 873-884
[6]  
Kullmann DM(2009)Endocannabinoid-mediated control of synaptic transmission Physiol. Rev. 89 309-380
[7]  
Jiang L(2002)Retrograde signaling in the regulation of synaptic transmission: focus on endocannabinoids Prog. Neurobiol. 68 247-286
[8]  
Xu J(2001)Presynaptic inhibition caused by retrograde signal from metabotropic glutamate to cannabinoid receptors Neuron 31 463-475
[9]  
Nedergaard M(2007)Endocannabinoid signaling triggered by NMDA receptor-mediated calcium entry into rat hippocampal neurons J. Physiol. (Lond.) 584 407-418
[10]  
Kang J(2001)Metabotropic glutamate receptors drive the endocannabinoid system in hippocampus J. Neurosci. 21 RC188-4177