Effect of Stimulation of α2-Adrenergic Receptors on Action Potential of Working Cardiomyocytes in Rat Atrium

被引：0
|
作者：
T. L. Zefirov
L. I. Faskhutdinov
N. I. Ziyatdinova
A. M. Galieva
A. L. Zefirov
机构：
[1] Kazan Federal University,Department of Anatomy, Physiology, and Human Health Protection
[2] Kazan State Medical University,Department of Normal Physiology
来源：
Bulletin of Experimental Biology and Medicine | 2019年 / 167卷
关键词：
α; -adrenergic receptor; clonidine; action potential; atrium; rat;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The study examined the effect of clonidine hydrochloride (10—9-10—5 М) on electrical activity of working cardiomyocytes in rat right atrium. Stimulation of α2-adrenergic receptor with clonidine changed electrical activity of the heart. All tested concentrations of the agonist lengthened the action potential and decreased the firing rate of cardiomyocytes in a dose-dependent manner. The maximum effects of clonidine were observed at concentration of 10—5 М.
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页码：603 / 605
页数：2
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