The quest to overcome resistance to EGFR-targeted therapies in cancer

被引：0
|
作者：
Curtis R Chong
Pasi A Jänne
机构：
[1] Lowe Center for Thoracic Oncology,Department of Medicine
[2] Dana-Farber Cancer Institute,undefined
[3] Brigham and Women's Hospital,undefined
[4] Belfer Institute for Applied Cancer Science,undefined
[5] Dana-Farber Cancer Institute,undefined
来源：
Nature Medicine | 2013年 / 19卷
关键词：
D O I：
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学科分类号：
摘要：
Despite the initial promise of cancer therapies targeted against the epidermal growth factor receptor (EGFR), tumors treated with these agents eventually develop resistance. In this Review, the authors outline the complex mechanisms by which tumors become resistant to EGFR-targeted drugs and antibodies and offer insights into new strategies that might be employed to circumvent therapeutic resistance.
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页码：1389 / 1400
页数：11
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