MicroRNA sequence polymorphisms and the risk of different types of cancer

被引：0
作者：
Ye Hu
Chen-Yang Yu
Ji-Lin Wang
Jian Guan
Hao-Yan Chen
Jing-Yuan Fang
机构：
[1] Renji Hospital,Division of Gastroenterology and Hepatology
[2] School of Medicine,Department of Otolaryngology
[3] Shanghai Jiao Tong University,undefined
[4] Shanghai Institution of Digestive Disease,undefined
[5] Key Laboratory of Gastroenterology & Hepatology,undefined
[6] Ministry of Health,undefined
[7] State Key Laboratory of Oncogene and Related Genes,undefined
[8] The Affiliated Sixth People's Hospital,undefined
[9] Otolaryngology Institute of Shanghai Jiao Tong University,undefined
来源：
Scientific Reports | / 4卷
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摘要：
MicroRNAs (miRNAs) participate in diverse biological pathways and may act as oncogenes or tumor suppressors. Single nucleotide polymorphisms (SNPs) in miRNAs (MirSNPs) might promote carcinogenesis by affecting miRNA function and/or maturation; however, the association between MirSNPs reported and cancer risk remain inconsistent. Here, we investigated the association between nine common MirSNPs and cancer risk using data from large scale case-control studies. Eight precursor-miRNA (pre-miRNA) SNPs (rs2043556/miR-605, rs3746444/miR-499a/b, rs4919510/miR-608, rs2910164/miR-146a, rs11614913/miR-196a2, rs895819/miR-27a, rs2292832/miR-149, rs6505162/miR-423) and one primary-miRNA (pri-miRNA) SNP (rs1834306/miR-100) were analyzed in 16399 cases and 21779 controls from seven published studies in eight common cancers. With a novel statistic, Cross phenotype meta-analysis (CPMA) of the association of MirSNPs with multiple phenotypes indicated rs2910164 C (P = 1.11E-03), rs2043556 C (P = 0.0165), rs6505162 C (P = 2.05E-03) and rs895819 (P = 0.0284) were associated with a significant overall risk of cancer. In conclusion, MirSNPs might affect an individual's susceptibility to various types of cancer.
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