Designable and dynamic single-walled stiff nanotubes assembled from sequence-defined peptoids

被引：0
作者：
Haibao Jin
Yan-Huai Ding
Mingming Wang
Yang Song
Zhihao Liao
Christina J. Newcomb
Xuepeng Wu
Xian-Qiong Tang
Zheng Li
Yuehe Lin
Feng Yan
Tengyue Jian
Peng Mu
Chun-Long Chen
机构：
[1] Physical Sciences Division,Department of Mechanical Engineering and Materials Science and Engineering Program
[2] Pacific Northwest National Laboratory,undefined
[3] Institute of Rheological Mechanics,undefined
[4] Xiangtan University,undefined
[5] School of Mechanical and Materials Engineering,undefined
[6] Washington State University,undefined
[7] Center for Biomaterials and Biopathways,undefined
[8] Department of Chemistry,undefined
[9] Zhejiang University,undefined
[10] School of Petroleum Engineering,undefined
[11] State Key Laboratory of Heavy Oil Processing,undefined
[12] China University of Petroleum (East China),undefined
[13] College of Chemistry and Chemical Engineering,undefined
[14] Linyi University,undefined
[15] State University of New York,undefined
来源：
Nature Communications | / 9卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Despite recent advances in the assembly of organic nanotubes, conferral of sequence-defined engineering and dynamic response characteristics to the tubules remains a challenge. Here we report a new family of highly designable and dynamic nanotubes assembled from sequence-defined peptoids through a unique “rolling-up and closure of nanosheet” mechanism. During the assembly process, amorphous spherical particles of amphiphilic peptoid oligomers crystallize to form well-defined nanosheets before folding to form single-walled nanotubes. These nanotubes undergo a pH-triggered, reversible contraction–expansion motion. By varying the number of hydrophobic residues of peptoids, we demonstrate tuning of nanotube wall thickness, diameter, and mechanical properties. Atomic force microscopy-based mechanical measurements show peptoid nanotubes are highly stiff (Young’s Modulus ~13–17 GPa). We further demonstrate the precise incorporation of functional groups within nanotubes and their applications in water decontamination and cellular adhesion and uptake. These nanotubes provide a robust platform for developing biomimetic materials tailored to specific applications.
引用
收藏
相关论文
共 78 条
[1]  
Shimizu T(2014)Self-organized nanotube materials and their application in bioengineering Polym. J. 46 831-858
[2]  
Hamley IW(2014)Peptide Nanotubes Angew. Chem. Int. Ed. 53 6866-6881
[3]  
Yu GC(2015)Supramolecular amphiphiles based on host-guest molecular recognition motifs Chem. Rev. 115 7240-7303
[4]  
Jie KC(2013)Development of toroidal nanostructures by self-assembly: rational designs and applications Acc. Chem. Res. 46 2888-2897
[5]  
Huang FH(2015)Ultrathin alternating copolymer nanotubes with readily tunable surface functionalities Angew. Chem. Int. Ed. 54 3621-3625
[6]  
Kim Y(2010)Loading and selective release of cargo in DNA nanotubes with longitudinal variation Nat. Chem. 2 319-328
[7]  
Li W(2012)Functional Supramolecular Polymers Science 335 813-817
[8]  
Shin S(2013)Janus cyclic peptide-polymer nanotubes Nat. Commun. 4 409-418
[9]  
Lee M(2010)Construction and optoelectronic properties of organic one-dimensional nanostructures Acc. Chem. Res. 43 10468-10471
[10]  
Chen JX(2015)Designed, helical protein nanotubes with variable diameters from a single building block J. Am. Chem. Soc. 137 1401-1443
12345678