Fructose malabsorption

被引：46
作者：
Karolin Ebert
Heiko Witt
机构：
[1] Technische Universität München (TUM),Pädiatrische Ernährungsmedizin, Klinikum rechts der Isar (MRI)
[2] Technische Universität München (TUM),Else Kröner
[3] Technische Universität München (TUM),Fresenius
来源：
Molecular and Cellular Pediatrics | / 3卷 / 1期
关键词：
Fructose malabsorption; Glucose transporters; GLUTs; Hydrogen breath test;
D O I：
10.1186/s40348-016-0035-9
中图分类号：
学科分类号：
摘要：
Incomplete intestinal absorption of fructose might lead to abdominal complaints such as pain, flatulence and diarrhoea. Whether defect fructose transporters such as GLUT5 or GLUT2 are involved in the pathogenesis of fructose malabsorption is a matter of debate. The hydrogen production by colonic bacteria is used for diagnosis with the hydrogen breath test. However, the appropriate fructose test dose for correct diagnosis is unclear. Subjects with fructose malabsorption show increased breath hydrogen levels and abdominal symptoms after fructose administration but do not report any symptoms when fructose is given together with glucose. This beneficial effect of glucose, however, cannot be explained yet but might be used for clinical care of these subjects.
引用
收藏
相关论文
共 144 条
  • [1] Enattah NS(2002)Identification of a variant associated with adult-type hypolactasia Nat Genet 30 233-237
  • [2] Sahi T(2002)Molecular basis for glucose-galactose malabsorption Cell Biochem Biophys 36 115-121
  • [3] Savilahti E(2009)Slc2a5 (Glut5) is essential for the absorption of fructose in the intestine and generation of fructose-induced hypertension J Biol Chem 284 5056-5066
  • [4] Terwilliger JD(1996)Molecular analysis of the fructose transporter gene (GLUT5) in isolated fructose malabsorption J Clin Invest 98 2398-2402
  • [5] Peltonen L(1991)Expression of human glucose transporters in Xenopus oocytes: kinetic characterization and substrate specificities of the erythrocyte, liver, and brain isoforms Biochemistry 30 5139-5145
  • [6] Järvelä I(2005)SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an essential transporter for mannose, 1,5-anhydro-D-glucitol, and fructose Life Sci 76 1039-1050
  • [7] Wright EM(1995)The GLUT5 hexose transporter is also localized to the basolateral membrane of the human jejunum Biochem J 309 7-12
  • [8] Turk E(2000)The diffusive component of intestinal glucose absorption is mediated by the glucose-induced recruitment of GLUT2 to the brush-border membrane Biochem J 350 155-162
  • [9] Martin MG(2002)The mutation spectrum of the facilitative glucose transporter gene SLC2A2 (GLUT2) in patients with Fanconi-Bickel syndrome Hum Genet 110 21-29
  • [10] Barone S(2014)Fructose transporters GLUT5 and GLUT2 expression in adult patients with fructose intolerance United European Gastroenterol J 2 14-21
12345678910