Activation of LXRs alleviates neuropathic pain-induced cognitive dysfunction by modulation of microglia polarization and synaptic plasticity via PI3K/AKT pathway

被引:0
|
作者
Siyi Han
Xiaoman Yuan
Fengtian Zhao
Anne Manyande
Feng Gao
Jie Wang
Wen Zhang
Xuebi Tian
机构
[1] Huazhong University of Science and Technology,Department of Anesthesiology, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College
[2] University of West London,School of Human and Social Sciences
[3] Chinese Academy of Sciences,Wuhan Institute of Physics and Mathematics
来源
Inflammation Research | 2024年 / 73卷
关键词
Liver X receptors; Neuropathic pain; Microglia polarization; Cognitive dysfunction; Neuroinflammation; Synaptic plasticity;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:157 / 174
页数:17
相关论文
共 50 条
  • [21] Nootkatone alleviates rotenone-induced Parkinson's disease symptoms through activation of the PI3K/Akt signaling pathway
    Yao, Ziwei
    Li, Jiayuan
    Bian, Lihua
    Li, Qiuyu
    Wang, Xiaomei
    Yang, Xue
    Wei, Xiaojia
    Wan, Guohui
    Wang, Yuqing
    Shi, Jinli
    Guo, Jianyou
    PHYTOTHERAPY RESEARCH, 2022, 36 (11) : 4183 - 4200
  • [22] Perioperative enriched environment attenuates postoperative cognitive dysfunction by upregulating microglia TREM2 via PI3K/Akt pathway in mouse model of ischemic stroke
    Yao, Yuchen
    Hu, Liru
    Li, Danni
    Wang, Yuhao
    Pan, Jian
    Fan, Dan
    FRONTIERS IN NEUROSCIENCE, 2024, 18
  • [23] Sema3A relieves neuropathic pain by reducing eIF2α phosphorylation via suppressing PI3K/Akt/mTOR pathway
    Hu, Tingting
    Pang, Miaoyi
    Sun, Qingyu
    Gou, Yu
    Liu, Jing
    Wang, Xiaotong
    Ma, Yiran
    Chen, Wen
    Wei, Chao
    Liu, Meng
    Ding, Yumeng
    Zhang, Yurui
    Liu, Dianxin
    Wu, Weihua
    Wang, Peipei
    Zhu, Hongwei
    Li, Qian
    Yang, Fei
    JOURNAL OF PAIN, 2025, 30
  • [24] Levomilnacipran Improves Lipopolysaccharide-Induced Dysregulation of Synaptic Plasticity and Depression-Like Behaviors via Activating BDNF/TrkB Mediated PI3K/Akt/mTOR Signaling Pathway
    Wu, Yuhan
    Zhu, Zhanpeng
    Lan, Tian
    Li, Shuhan
    Li, Ye
    Wang, Changmin
    Feng, Yabo
    Mao, Xueqin
    Yu, Shuyan
    MOLECULAR NEUROBIOLOGY, 2024, 61 (07) : 4102 - 4115
  • [25] Breviscapine restores sevoflurane-induced cognitive dysfunction by activating the PI3K/Akt pathway and inhibiting NF-KB
    Mao, Qingju
    Cheng, Ke
    Zhang, Zhen
    QUALITY ASSURANCE AND SAFETY OF CROPS & FOODS, 2023, 15 (01) : 160 - 168
  • [26] Achyranthes bidentata polypeptide alleviates neurotoxicity of lipopolysaccharide-activated microglia via PI3K/Akt dependent NOX2/ROS pathway
    Wang, Yitong
    Ge, Xiangyu
    Yu, Shu
    Cheng, Qiong
    ANNALS OF TRANSLATIONAL MEDICINE, 2021, 9 (20)
  • [27] Swertiamarin ameliorates cognitive dysfunction by improving hyperglycemia and neuroinflammation in type 2 diabetic rats via activation of the PI3K/AKT/GSK3(3 signaling pathway
    Tan, Bingyin
    Liu, Li
    Wu, Tao
    Yuan, Fangjie
    Wang, Cheng
    CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY, 2024, 49 (04) : 425 - 435
  • [28] Effect of HDAC2/Inpp5f on neuropathic pain and cognitive function through regulating PI3K/Akt/GSK-3β signal pathway in rats with neuropathic pain
    Yuan, Lili
    Liu, Caihua
    Wan, Yingchun
    Yan, Hong
    Li, Tao
    EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2019, 18 (01) : 678 - 684
  • [29] Taselisib moderates neuropathic pain through PI3K/AKT signaling pathway in a rat model of chronic constriction injury
    You, Hai-Ping
    Xu, Chong-Jun
    Zhang, Li-Hong
    Chen, Zhi-Yuan
    Liu, Wei-Feng
    Wang, Hong-Geng
    He, He-Fan
    Zhang, Liang-Cheng
    BRAIN RESEARCH BULLETIN, 2023, 199
  • [30] Activation of CNR1/PI3K/AKT Pathway by Tanshinone IIA Protects Hippocampal Neurons and Ameliorates Sleep Deprivation-Induced Cognitive Dysfunction in Rats
    Li, Zi-Heng
    Cheng, Li
    Wen, Chun
    Ding, Li
    You, Qiu-Yun
    Zhang, Shun-Bo
    FRONTIERS IN PHARMACOLOGY, 2022, 13