AHR signaling in the development and function of intestinal immune cells and beyond

被引：0
作者：
Luisa Cervantes-Barragan
Marco Colonna
机构：
[1] Washington University School of Medicine,Department of Pathology and Immunology
来源：
Seminars in Immunopathology | 2018年 / 40卷
关键词：
Innate lymphoid cells; ILCs; Aryl hydrocarbon receptor; AHR; DP IEL;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The intestinal immune system is challenged daily with the task of recognizing and eliminating pathogens while simultaneously tolerating dietary and commensal antigens. All components must effectively coordinate to differentiate a continual barrage of environmental cues and mount appropriate responses dependent on the nature of the stimuli encountered. Playing a pivotal role, the aryl hydrocarbon receptor (AHR) is a chemical sensor that detects both dietary and microbial cues and is important for development, maintenance, and function of several types of intestinal immune cells, particularly innate lymphoid cells (ILCs) and T cells. In this review, we will highlight recent advances in our knowledge of the role of AHR signaling in ILCs, T cells, B cells, and dendritic cells.
引用
收藏
页码：371 / 377
页数：6
相关论文
共 623 条
[1]  
Gu YZ(2000)The PAS superfamily: sensors of environmental and developmental signals Annu Rev Pharmacol Toxicol 40 519-561
[2]  
Hogenesch JB(2010)Mammalian Per-Arnt-Sim proteins in environmental adaptation Annu Rev Physiol 72 625-645
[3]  
Bradfield CA(2004)The mammalian basic helix-loop-helix/PAS family of transcriptional regulators Int J Biochem Cell Biol 36 189-204
[4]  
McIntosh BE(2007)Microarray analysis of the AHR system: tissue-specific flexibility in signal and target genes Toxicol Appl Pharmacol 220 320-332
[5]  
Hogenesch JB(1988)Association of the Ah receptor with the 90-kDa heat shock protein J Biol Chem 263 13802-13805
[6]  
Bradfield CA(1997)Ligand-dependent interaction of the aryl hydrocarbon receptor with a novel immunophilin homolog in vivo J Biol Chem 272 11452-11456
[7]  
Kewley RJ(1998)Hepatitis B virus X-associated protein 2 is a subunit of the unliganded aryl hydrocarbon receptor core complex and exhibits transcriptional enhancer activity Mol Cell Biol 18 978-988
[8]  
Whitelaw ML(1996)A pathway of multi-chaperone interactions common to diverse regulatory proteins: estrogen receptor, Fes tyrosine kinase, heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor Cell Stress Chaperones 1 237-250
[9]  
Chapman-Smith A(1994)A cellular factor stimulates ligand-dependent release of hsp90 from the basic helix-loop-helix dioxin receptor Mol Cell Biol 14 2438-2446
[10]  
Frericks M(1995)Identification of functional domains of the aryl hydrocarbon receptor J Biol Chem 270 29270-29278
12345678910