Leptin-mediated meta-inflammation may provide survival benefit in patients receiving maintenance immunotherapy for extensive-stage small cell lung cancer (ES-SCLC)

被引：0

作者：

Emanuele Vita

Alessio Stefani

Geny Piro

Luca Mastrantoni

Marco Cintoni

Giuseppe Cicchetti

Ileana Sparagna

Federico Monaca

Guido Horn

Jacopo Russo

Diletta Barone

Mariantonietta Di Salvatore

Rocco Trisolini

Filippo Lococo

Ciro Mazzarella

Alessandra Cancellieri

Carmine Carbone

Anna Rita Larici

Maria Cristina Mele

Sara Pilotto

Michele Milella

Giampaolo Tortora

Emilio Bria

机构：

[1] Fondazione Policlinico Universitario Agostino Gemelli IRCCS,UOSD Oncologia Toraco

[2] Fondazione Policlinico Universitario Agostino Gemelli IRCCS,Polmonare, Comprehensive Cancer Center

[3] Università Cattolica del Sacro Cuore,UOC Oncologia Medica, Comprehensive Cancer Center

[4] Fondazione Policlinico Universitario Agostino Gemelli IRCCS,UOC Nutrizione Clinica

[5] Fondazione Policlinico Universitario Agostino Gemelli IRCCS,UOC Radiologia Toracica e Cardiovascolare, Advanced Radiodiagnostics Center

[6] Fondazione Policlinico Universitario Agostino Gemelli IRCCS,UOC Pneumologia Interventistica

[7] Fondazione Policlinico Universitario Agostino Gemelli IRCCS,UOC Chirurgia Toracica

[8] Fondazione Policlinico Universitario Agostino Gemelli IRCCS,UOC Radioterapia Oncologica

[9] Fondazione Policlinico Universitario Agostino Gemelli IRCCS,UOC Anatomia Patologica

[10] Verona University Hospital Trust,UOC Oncologia Medica

来源：

Cancer Immunology, Immunotherapy | 2023年 / 72卷

关键词：

SCLC; Immunotherapy; Metabolomics; Leptin; Adipokines; Obesity;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

引用

页码：3803 / 3812

页数：9

共 49 条

[21] A nomogram to predict the overall survival of patients with symptomatic extensive-stage small cell lung cancer treated with thoracic radiotherapy [J].

Yuan, Xun ;

Zheng, Zhiqin ;

Liu, Fangfang ;

Gao, Yuan ;

Zhang, Wenhui ;

Berardi, Rossana ;

Mohindra, Pranshu ;

Zhu, Zhengfei ;

Lin, Jie ;

Chu, Qian .

TRANSLATIONAL LUNG CANCER RESEARCH, 2021, 10 (05) :2163-+

[22] Efficacy and safety of first-line immunotherapy-based regimens for patients with extensive-stage small cell lung cancer: a systematic review and network meta-analysis [J].

Zhang, Wengang ;

Zhao, Wencheng ;

Zhang, Xinyu ;

Guo, Zhiyi ;

Ye, Li ;

Chen, Zhimin ;

Xu, Kandi ;

Zhao, Lishu ;

Liu, Xinyue ;

Liu, Yujin ;

Wang, Hao ;

He, Yayi .

TRANSLATIONAL LUNG CANCER RESEARCH, 2025, 14 (01) :163-175

[23] Randomized phase II clinical trial of cisplatin/carboplatin and etoposide (PE) alone or in combination with nivolumab as frontline therapy for extensive-stage small cell lung cancer (ES-SCLC): ECOG-ACRIN EA5161 [J].

Leal, Ticiana A. ;

Wang, Yating ;

Dowlati, Afshin ;

Chay, Christopher H. ;

Chen, Yuanbin ;

Mohindra, Amit R. ;

Razaq, Mohammad ;

Ajuja, Harish G. ;

Liu, Jijun ;

King, David M. ;

Sumey, Christopher J. ;

Ramalingam, Suresh S. .

CANCER, 2025, 131 (12)

[24] Chemotherapy or chemo-immunotherapy as first-line treatment for extensive-stage small-cell lung cancer - a meta-analysis [J].

Chen, Ching-Yi ;

Chen, Wang-Chun ;

Hung, Chao-Ming ;

Wei, Yu-Feng .

IMMUNOTHERAPY, 2021, 13 (14) :1165-1178

[25] The PESGA Trial: A Prospective, Open-Label, Single-Arm, Phase II Study to Evaluate First Line Therapy for Extensive-Stage Small Cell Lung Cancer (ES-SCLC) Patients, Treated by Induction Carboplatin/Etoposide/Pembrolizumab Followed by Maintenance of Pembrolizumab/ Sacituzumab Govitecan [J].

Roisman, Laila C. ;

Mann, Shir ;

Basel, Afifi ;

Marei, Ranin ;

Krayim, Belal ;

Kornev, Gleb ;

Asna, Noam ;

Peled, Nir .

CLINICAL LUNG CANCER, 2025, 26 (04) :267-270

[26] Efficacy and safety of first-line immunotherapy plus chemotherapy in treating patients with extensive-stage small cell lung cancer: a Bayesian network meta-analysis [J].

Zhang, Tianming ;

Li, Wenjun ;

Diwu, Danbei ;

Chen, Lijun ;

Chen, Xi ;

Wang, Hong .

FRONTIERS IN IMMUNOLOGY, 2023, 14

[27] Comprehensive genomic and spatial immune infiltration analysis of survival outliers in extensive-stage small cell lung cancer receiving first-line chemoimmunotherapy [J].

Jiang, Yuxin ;

Xie, Jingyuan ;

Cheng, Qinpei ;

Cai, Zijing ;

Xu, Ke ;

Lu, Wanjun ;

Wang, Fufeng ;

Wu, Xiaoying ;

Song, Yong ;

Lv, Tangfeng ;

Zhan, Ping .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2024, 141

[28] Safety and efficacy of thoracic radiotherapy combined with chemo-immunotherapy in patients with extensive-stage small cell lung cancer: a multicenter retrospective analysis [J].

Cai, Zijing ;

Gu, Xiaoling ;

Xie, Jingyuan ;

Cheng, Di ;

Chen, Jiayan ;

Cheng, Jing ;

Ye, Jinjun ;

Lv, Tangfen .

TRANSLATIONAL LUNG CANCER RESEARCH, 2023, 12 (10) :1987-+

[29] Clinical outcomes and synergistic effect between radiotherapy and immunotherapy in patients with extensive-stage small cell lung cancer: a real-world study [J].

Sun, Meiling ;

Ji, Huaijun ;

Deng, Fang ;

Li, Jingyi ;

Xu, Ning ;

Li, Yu .

BMC CANCER, 2024, 24 (01)

[30] Patients with Extensive-Stage Small Cell Lung Cancer Harboring Less Than 4 Metastatic Sites May Benefit from Immune Checkpoint Inhibitor Rechallenge by Reshaping Tumor Microenvironment [J].

Shang, Xiaoling ;

Zhang, Chenyue ;

Lv, Yuanyuan ;

Zhang, Xiaoxiao ;

Guo, Kaiyue ;

Li, Huijuan ;

Wang, Haiyong .

IMMUNOTARGETS AND THERAPY, 2024, 13 :571-583

← 1 2 3 4 5 →