Does the Mouse Mammary Gland Arise from Unipotent or Multipotent Mammary Stem/Progenitor Cells?

被引：0
|
作者：
Gilbert H. Smith
Daniel Medina
机构：
[1] Mammary Stem Cell Biology,Molecular and Cellular Biology
[2] BRL,undefined
[3] CCR,undefined
[4] NCI,undefined
[5] NIH,undefined
[6] Baylor College of Medicine,undefined
来源：
Journal of Mammary Gland Biology and Neoplasia | 2018年 / 23卷
关键词：
mammary; stem/progenitor cell; lineage-tracing; mouse;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The presence of long-lived lineage restricted progenitor and multipotent progenitor cells in adult mouse mammary gland for cancer development is compelling. Mammary cancers are phenotypically diverse This might be explained by transformation of long-lived, lineage-limited progenitor subpopulations. Mammary multipotent epithelial stem cells and their environmental niches must be considered, since their niche(s), once empty might be occupied by lineage-limited progenitors that are proximal. The existence of premalignant mammary populationst that manifest characteristics of lineage limitation argues strongly for this proposition.
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页码：1 / 3
页数：2
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