Investigation of Extracellular L-Citrulline Concentration in the Striatum During Alcohol Withdrawal in Rats

被引：0
作者：
M. Z. Gören
F. Aricioglu-Kartal
T. Yurdun
I. T. Uzbay
机构：
[1] Gülhane Military Medical Academy,Department of Medical Pharmacology, Psychopharmacology Research Unit
[2] Marmara University,Department of Pharmacology
[3] Faculty of Pharmacy,Department of Pharmaceutical Toxicology
[4] Marmara University,Department of Pharmacology and Clinical Pharmacology
[5] Faculty of Pharmacy,undefined
[6] Marmara University,undefined
[7] School of Medicine,undefined
来源：
Neurochemical Research | 2001年 / 26卷
关键词：
Alcohol withdrawal; rat striatum; microdialysis; L-citrulline, L-NAME; nitric oxide;
D O I：
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中图分类号：
学科分类号：
摘要：
In this study, changes in striatal extracellular L-citrulline concentrations were investigated hourly for 5 h following alcohol withdrawal in chronic alcohol feeding Wistar rats. Alcohol (7.2% ethyl alcohol, v/v) was given to rats as modified liquid diet for 20 days. Signs of alcohol withdrawal appeared from the 1st h of alcohol withdrawal and the total alcohol withdrawal scores remained higher during the course of experiments. The mean of basal levels of L-citrulline in the microdialysis samples collected in conscious rat model from the striatum of control and alcoholized rats were found to be 1.28 ± 0.48 μM and 0.35 ± 0.08 μM, respectively. L-citrulline levels in the striatum of alcoholized rats increased by 4 folds significantly within 1 h following alcohol withdrawal. The increased striatal L-citrulline concentration was blocked by NG-nitro-L-arginine methyl ester (L-NAME; 60 mg/kg), a nitric oxide synthase inhibitor, pretreatment. Our results indicate an increased L-citrulline level in the rat striatum during early alcohol withdrawal and this situation may be related to an increased nitric oxide production.
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页码：1327 / 1333
页数：6
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