Family history of malignancies and risk of breast cancer: prospective data from the Shanghai women’s health study

被引：0
作者：
Briseis A. Kilfoy
Yawei Zhang
Xiao-Ou Shu
Yu-Tang Gao
Bu-Tian Ji
Gong Yang
Hong Lan Li
Nathaniel Rothman
Wong-Ho Chow
Wei Zheng
机构：
[1] Yale University,School of Epidemiology and Public Health
[2] Department of Health and Human Services,Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
[3] Vanderbilt University,Center for Health Services Research, Department of Medicine
[4] Vanderbilt University,Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt
[5] Shanghai Cancer Institute,Ingram Cancer Center
来源：
Cancer Causes & Control | 2008年 / 19卷
关键词：
Family history; Breast cancer;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A population-based cohort study was conducted in Shanghai, China, to investigate the relationship between family cancer history in first-degree relatives and risk of breast cancer. A total of 570 newly diagnosed breast cancer patients were identified from the cohort of 73,222 women during the follow-up period. Breast cancer risk was elevated (RR = 1.74, 95% CI: 1.10–2.73) for those with a family history of breast cancer and the risk was stronger for women who were younger than 55 years (RR = 2.07, 95% CI: 1.17–3.64). In addition, a significantly increased risk was observed for women with a family history of leukemia (RR = 2.06; 95% CI: 1.02–4.15) and among younger women, those who reported having a family history of any cancer (RR = 1.41, 95% CI: 1.10–1.82), lung cancer (RR = 1.72, 95% CI: 1.12–2.65), and esophageal cancer (RR = 2.99, 95% CI: 1.62–5.51). This cohort study suggests that, as previously observed in high risk populations, family history plays an important role in breast cancer also in a low risk population. The link between breast cancer risk and family history of cancers of the lung and esophagus, as well as leukemia, warrants further investigation.
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页码：1139 / 1145
页数：6
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